目的 研究心脈隆注射液聯(lián)合磷酸肌酸鈉治療慢性心力衰竭的臨床效果。方法 選取2014年10月-2017年1月延安市人民醫(yī)院收治的慢性心力衰竭患者115例，隨機(jī)分為對(duì)照組（57例）和治療組（58例）。對(duì)照組靜脈滴注注射用磷酸肌酸鈉，1 g加入5%葡萄糖溶液250 mL，2次/d；治療組在對(duì)照組的基礎(chǔ)上靜脈滴注心脈隆注射液，5 mg/kg加入生理鹽水250 mL，2次/d。兩組患者均治療14 d。評(píng)價(jià)兩組患者臨床療效，同時(shí)比較治療前后兩組患者心功能指標(biāo)、腦鈉肽（BNP）水平和6 min步行距離。結(jié)果 治療后，對(duì)照組的臨床總有效率為75.8%，顯著低于治療組的90.5%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者左心室舒張末期內(nèi)徑（LVEDD）、左心室收縮末期內(nèi)徑（LVESD）均顯著降低，左室射血分?jǐn)?shù)（LVEF）顯著上升，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組患者心功能指標(biāo)改善程度顯著優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者BNP均顯著降低，6 min步行距離顯著增加，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組患者BNP水平和6 min距離優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 心脈隆注射液聯(lián)合磷酸肌酸鈉治療慢性心力衰竭臨床療效較好，顯著改善左心室功能，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinic effect of Xinmailong Injection combined with creatine phosphate sodium in treatment of chronic heart failure. Methods Patients (115 cases) with chronic heart failure in Yan'an People's Hospital from October 2014 to January 2017 were randomly divided into control (57 cases) and treatment (58 cases) groups. Patients in the control group were iv administered with Creatine Phosphate Sodium for injection, 1 g added into 5% glucose solution 250 mL, twice daily. Patients in the treatment group were iv administered with Xinmailong Injection on the basis of the control group, 5 mg/kg added into normal saline 250 mL, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and cardiac function index, BNP level and 6 min walking distance in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 75.8%, which was significantly lower than 90.5% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the LVEDD, LVESD in two groups were significantly decreased, but LVEF was significantly increased, and there were differences in the same group (P<0.05). And the improvement of cardiac function index in the treatment group was significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the BNP in two groups were significantly decreased, but 6 min walking distance was significantly increased, and the difference was statistically significant in the same group (P<0.05). And the BNP level and 6 min walking distance in the treatment group was significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xinmailong Injection combined with creatine phosphate sodium can significantly improve the efficiency and the left ventricular function in treatment of chronic heart failure, which has a certain clinical application value.