目的 探討杏丁注射液聯(lián)合還原型谷胱甘肽治療慢性腎衰竭患者的臨床效果。方法 選取2016年1月-2016年12月在首都醫(yī)科大學(xué)附屬北京潞河醫(yī)院接受治療的慢性腎衰竭患者98例，隨機(jī)分為對(duì)照組和治療組，每組各49例。對(duì)照組靜脈注射注射用還原型谷胱甘肽，1.8 g/次，1次/d。治療組患者在對(duì)照組的基礎(chǔ)上靜脈注射杏丁注射液，20 mL溶于生理鹽水250 mL，1次/d。兩組患者均治療4周。評(píng)價(jià)兩組患者臨床療效，同時(shí)比較治療前后兩組患者臨床癥狀改善情況以及尿蛋白、血清肌酐（SCr）、尿素氮（BUN）和肌酐清除率（Ccr）。結(jié)果 治療后，對(duì)照組和治療組總有效率分別為83.67%、95.92%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者惡心、嘔吐、四肢無(wú)力和食欲不振等臨床癥狀均明顯好轉(zhuǎn)，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組患者臨床癥狀改善情況顯著優(yōu)于對(duì)照組患者，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者尿蛋白、Scr和BUN均顯著降低，Ccr顯著升高，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組患者尿蛋白、Scr、BUN和Ccr含量明顯優(yōu)于對(duì)照組患者，兩組患者比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 杏丁注射液聯(lián)合還原型谷胱甘肽治療慢性腎衰竭患者應(yīng)用能夠有效改善患者生化指標(biāo)和臨床癥狀，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical effect of Xingding Injection combined with reduced glutathione in treatment of chronic renal failure. Methods Patients (98 cases) with chronic renal failure in Beijing Luhe Hospital of Capital Medical University from January 2016 to December 2016 were randomly divided into control and treatment groups, and each group had 49 cases. Patients in the control group were iv administered with Reduced Glutathione for injection, 1.8 g/time, once daily. Patients in the treatment group were iv administered with Xingding Injection on the basis of the control group, 20 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptoms, urine protein, Scr, BUN and Ccr in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 83.67% and 95.92%, respectively, and there were differences between two groups (P<0.05). After treatment, the nausea, vomiting, myasthenia of limbs and anorexia in two groups was obviously improved, and the difference was statistically significant in the same group (P<0.05). And the improvement of clinical symptoms in the treatment group was obviously better higher than that the control group, with significant difference between two groups (P<0.05). After treatment, the urine protein, Scr and BUN in two groups was significantly decreased, but Ccr was significantly increased, and there were differences in the same group (P<0.05). And these indexes in the treatment group were obviously better than those the control group, with significant difference between two groups (P<0.05). Conclusion Xingding Injection combined with reduced glutathione can effectively improve the biochemical indicators and clinical symptoms in treatment of chronic renal failure, which has a certain clinical application value.