目的 探討葛根素注射液聯(lián)合神經(jīng)節(jié)苷脂鈉治療突發(fā)性耳聾的臨床療效。方法 選取2015年10月-2017年2月在宜興市人民醫(yī)院進(jìn)行治療的100例突發(fā)性耳聾患者為研究對象，根據(jù)用藥的差別分為對照組（50例）和治療組（50例）。對照組靜脈滴注單唾液酸四己糖神經(jīng)節(jié)苷脂鈉注射液，40 mg加入生理鹽水100 mL，1次/d。治療組在對照組的基礎(chǔ)上靜脈滴注葛根素注射液，400 mg加入生理鹽水250 mL，1次/d。兩組患者均治療10 d。評價兩組患者臨床療效，同時比較治療前后兩組患者血清細(xì)胞因子水平、血液流變學(xué)指標(biāo)和力閾值。結(jié)果 治療后，對照組和治療組總有效率分別為80.00%和96.00%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者血漿內(nèi)皮素（ET）、可溶性血管細(xì)胞間黏附分子-1（sVCAM-1）水平降低，降鈣素基因相關(guān)肽（CGRP）水平增高，同組比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組患者血清細(xì)胞因子水平顯著優(yōu)于對照組（P<0.05）。治療后，兩組患者血漿黏度（PV）、全血黏度高切（HS）、紅細(xì)胞聚集指數(shù)（EAI）、纖維蛋白原（FIB）均顯著降低（P<0.05）；且治療組患者血液流變學(xué)指標(biāo)明顯低于對照組（P<0.05）。治療后，兩組患者聽力閾值均顯著下降（P<0.05）；且治療組患者聽力閾值明顯低于對照組（P<0.05）。結(jié)論 葛根素注射液聯(lián)合神經(jīng)節(jié)苷脂鈉治療突發(fā)性耳聾可有效改善血液流變學(xué)指標(biāo)和血管內(nèi)皮功能，有利于聽力恢復(fù)，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical efficacy of Puerarin Injection combined with ganglioside sodium in treatment of sudden deafness. Methods Patients (100 cases) with sudden deafness in Yixing People's Hospital from October 2015 to February 2017 were divided into control (50 cases) and treatment (50 cases) groups according to different treatments. Patients in the control group were iv administered with Monosialotetrahexosylganglioside Sodium Injection, 40 mg added into normal saline 100mL, once daily. Patients in the treatment group were iv administered with Puerarin Injection on the basis of the control group, 400 mg added into normal saline 250mL, once daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, and serum cytokines, hemorheological indexes and auditory threshold in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 80.00% and 96.00%, respectively, and there were differences between two groups (P<0.05). After treatment, the ET and sVCAM-1 level in two groups was significantly decreased, CGRP level was significantly increased, and the difference was statistically significant in the same group (P<0.05). And the serum cytokines in the treatment group were obviously better than that in the control group, with significant difference between two groups (P<0.05). After treatment, the PV, HS, FIB and EAI in two groups was significantly decreased (P<0.05), and the hemorheological indexes in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the auditory threshold in two groups was significantly decreased (P<0.05), and the auditory threshold in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion Puerarin Injection combined with ganglioside sodium can improve the hemorheological indexes and vascular endothelial function in treatment of sudden deafness, and is conducive to the recovery of hearing, which has a certain clinical application value.