目的 探討丹紅注射液聯(lián)合硝苯地平治療冠心病無(wú)癥狀性心肌缺血的臨床療效。方法 選取2014年1月-2016年12月在新疆生產(chǎn)建設(shè)兵團(tuán)第九師醫(yī)院進(jìn)行治療的70例冠心病無(wú)癥狀性心肌缺血患者為研究對(duì)象，依據(jù)用藥差別分成對(duì)照組（35例）和治療組（35例）。對(duì)照組患者口服硝苯地平片，10 mg/次，3次/d。治療組在對(duì)照組基礎(chǔ)上靜脈滴注丹紅注射液，20 mL加入5%葡萄糖溶液250 mL，1次/d。兩組均治療14 d。評(píng)價(jià)兩組患者臨床療效，同時(shí)比較治療前后兩組患者24 h心電圖、心率（HR）、心肌耗氧量指數(shù)（RPP）和血管內(nèi)皮功能變化。結(jié)果 治療后，對(duì)照組和治療組總有效率分別為71.43%和91.43%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者ST段壓低幅度、壓低次數(shù)和持續(xù)時(shí)間以及HR和RPP均顯著降低，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組比對(duì)照組降低的更明顯，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組血清可溶性細(xì)胞黏附因子-1（sICAM-1）、可溶性血管細(xì)胞黏附分子-1（sVCAM-1）水平顯著降低，血管內(nèi)皮生長(zhǎng)因子（VEGF）和NO水平顯著增高，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組患者血管內(nèi)皮功能因子水平明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 丹紅注射液聯(lián)合硝苯地平治療冠心病無(wú)癥狀性心肌缺血可有效降低心肌耗氧量，改善血管內(nèi)皮功能，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy of Danhong Injection combined with nifedipine in treatment of silent myocardial ischemia of coronary heart disease. Methods Patients (70 cases) with silent myocardial ischemia of coronary heart disease in the Ninth Divisions' Hospital of Xinjiang Production and Construction Corps from January 2014 to December 2016 were divided into control (35 cases) and treatment (35 cases) groups according to different treatments. Patients in the control group were po administered with Nifedipine Tablets, 10 mg/time, three times daily. Patients in the treatment group were iv administered with Danhong Injection on the basis of the control group, 20 mL added into 5% glucose injection 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the change of 24 h ECG, HR, RPP, and vascular endothelial function in two groups before and after treatment was compared. Results After treatment, the clinical efficacy in the control and treatment groups were 71.43% and 91.43%, respectively, and there were differences between two groups (P<0.05). After treatment, the HR and RPP, and depression, depression times and depression duration of ST-segment in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And these indexes in the treatment group were obviously lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the serum sICAM-1 and sVCAM-1 level in two groups was significantly decreased, but VEGF and NO level were significantly increased, and there were differences in the same group (P<0.05). And the vascular endothelial function in the treatment group was significantly better than that in the control group, with significant difference between two groups (P<0.05). Conclusion Danhong Injection combined with nifedipine in treatment of silent myocardial ischemia of coronary heart disease can effectively reduce myocardial oxygen consumption and improve vascular endothelial function, which has a certain clinical application value.