目的 探討金葉敗毒顆粒聯(lián)合熱毒寧注射液治療小兒病毒性肺炎的臨床效果。方法 選取陜西省人民醫(yī)院兒童病院2016年3月-2017年3月收治的小兒病毒性肺炎患者80例，隨機分為對照組（40例）和治療組（40例）。對照組患兒靜脈滴注熱毒寧注射液，2~5歲患兒，5 mL加入生理鹽水100 mL，滴速30~40滴/min，1次/d；6~10歲患兒，10 mL加入生理鹽水200 mL，滴速30~60滴/min，1次/d。治療組患兒在對照組的基礎上口服金葉敗毒顆粒，10 g/次，3次/d。兩組患兒均治療7 d。評價兩組患兒臨床療效，同時比較治療前后兩組患兒臨床癥狀、體征改善情況和臨床癥狀、體征評分以及血清血清白介素（IL）-6、IL-8、腫瘤壞死因子（TNF）-α水平。結果 治療后，對照組患兒總有效率為72.50%，顯著低于治療組的92.50%，兩組比較差異具有統(tǒng)計學意義。治療后，治療組退熱時間、肺部濕啰音消失時間、咳嗽消失時間和咽痛消失時間均顯著短于對照組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組患兒咳嗽評分、氣促評分、體溫評分、肺部啰音評分、總評分均顯著降低（P<0.05）；且治療組上述評分顯著低于對照組（P<0.05）。治療后，兩組IL-6、IL-8、TNF-α炎性指標水平均顯著低于治療前（P<0.05）；且與對照組相比，治療組上述指標降低更明顯（P<0.05）。結論 金葉敗毒顆粒聯(lián)合熱毒寧注射液治療小兒病毒性肺炎能有效緩解患者的臨床癥狀、體征，減少炎性反應發(fā)生，具有一定的臨床推廣應用價值。

Objective To explore the clinical effect of Jinye Baidu Granules combined with Reduning Injection in treatment of children with viral pneumonia. Methods Children (80 cases) with viral pneumonia in Childrens' Hospital of Shaanxi Provincial People's Hospital from March 2016 to March 2017 were randomly divided into control (40 cases) and treatment (40 cases) groups. Children in the control group were iv administered with Reduning Injection, 5 mL added into 100 mL normal saline for 2-5 years old children, the dropping speed was 30-40 drops/min, and 10 mL added into 200 mL normal saline for 6-10 years old children, the dropping speed was 30-60 drops/min, once daily. Children in the treatment group were po administered with Jinye Baidu Granules on the basis of the control group, 10 g/time, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptoms and signs, symptoms and signs scores, serum levels of IL-6, IL-8 and TNF-α in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 72.50%, which was significantly lower than 92.50% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the pyretolysis time, and the disappearance time of lung wet rales, cough and sore throat in treatment group was significantly shorter than that in the control group, with significant difference between two groups (P<0.05). After treatment, the scores of cough, shortness of breath, body temperature and pulmonary rales in two groups was significantly decreased (P<0.05). And these scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the IL-6, IL-8 and TNF-α levels in two groups were significantly decreased (P<0.05). And the levels in the treatment group were significantly lower than those in the control group (P<0.01). Conclusion Jinye Baidu Granules combined with Reduning Injection can effectively alleviate clinical symptoms and signs of children with viral pneumonia, and reduce the occurrence of inflammatory reaction, which has a certain clinical application value.