目的 分析肌氨肽苷注射液聯(lián)合α-硫辛酸治療糖尿病周圍血管神經(jīng)病變的臨床療效。方法 選取2016年1月-2017年1月在菏澤市立醫(yī)院接受治療的糖尿病周圍血管神經(jīng)病變患者80例，隨機(jī)分成對照組（40例）和治療組（40例）。對照組患者靜脈滴注硫辛酸注射液，300 mg加入250 mL生理鹽水，1次/d。治療組在對照組的基礎(chǔ)上靜脈滴注肌氨肽苷注射液，10 mL加入250 mL生理鹽水，1次/d。兩組患者均治療2周。評價兩組患者臨床療效，同時比較治療前后兩組患者神經(jīng)傳導(dǎo)速度、血清學(xué)指標(biāo)和TCSS評分。結(jié)果 治療后，對照組和治療組的總有效率分別為62.50%、87.50%；兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者腓總神經(jīng)、脛前神經(jīng)運(yùn)動傳導(dǎo)速度（MCV）和感覺神經(jīng)傳導(dǎo)速度（SCV）均顯著增加（P<0.05）；且治療組神經(jīng)傳導(dǎo)速度增加的更顯著（P<0.05）。治療后，兩組血清內(nèi)皮素（ET）水平明顯降低，一氧化氮（NO）、超氧化物歧化酶（SOD）水平明顯增高，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組上述指標(biāo)顯著優(yōu)于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組TCSS評分均降低（P<0.05）；且治療組比對照組降低的更顯著（P<0.05）。結(jié)論 肌氨肽苷注射液聯(lián)合α-硫辛酸治療糖尿病周圍血管神經(jīng)病變具有較好的療效，有利于臨床癥狀的改善，還可提高神經(jīng)傳導(dǎo)速度，具有一定的臨床推廣應(yīng)用價值。

Objective To analysis the clinical efficacy of Muscular Amino Acids and Peptides and Nucleosides Injection combined with α-thioctic acid in treatment of diabetic peripheral neuropathy. Methods Patients (80 cases) with diabetic peripheral neuropathy in Heze Municiple Hospital from January 2016 to January 2017 were randomly divided into control (40 cases) and treatment (40 cases) groups. Patients in the control group were iv administered with Thioctic Acid Injection, 300 mg added into normal saline 250 mL, once daily. Patients in the treatment group were iv administered with Muscular Amino Acids and Peptides and Nucleosides Injection on the basis of the control group, 10 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the nerve conduction velocity, serum indexes, and TCSS scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 62.50% and 87.50%, respectively, and there were differences between two groups (P<0.05). After treatment, the common peroneal nerve velocity, MCV, and SCV in two groups were significantly increased (P<0.05). And the increase of the nerve conduction velocity in the treatment group was more significantly than that in the control group (P<0.05). After treatment, the ET level in two groups was significantly decreased, NO and SOD levels were significantly increased, the difference was statistically significant in the same group (P<0.05). And these indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the TCSS scores in two groups were significantly decreased (P<0.05). And the increase of the TCSS score in the treatment group was more significantly than that in the control group (P<0.05). Conclusion Muscular Amino Acids and Peptides and Nucleosides Injection combined with thioctic acid has a significant effect in treatment of diabetic peripheral neuropathy, can effectively improve the clinical symptoms and nerve conduction velocity, which has a certain clinical application value.