目的 探討前列地爾注射液聯(lián)合甲鈷胺片和長(zhǎng)春西汀片治療急性耳鳴的臨床療效。方法 選取2015年6月-2016年9月在天津中醫(yī)藥大學(xué)第一附屬醫(yī)院耳鼻喉科治療的耳鳴患者87例，隨機(jī)分為對(duì)照組（44例）和治療組（43例）。對(duì)照組口服甲鈷胺片，0.5 mg/次，3次/d；且口服長(zhǎng)春西汀片，5 mg/次，3次/d。治療組在對(duì)照組基礎(chǔ)上靜脈注射前列地爾注射液，10 μg加入到生理鹽水10 mL中，1次/d。兩組均治療2周。觀察兩組臨床療效，比較兩組耳鳴臨床癥狀評(píng)分和嚴(yán)重程度積分變化。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為61.36%、86.05%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組耳鳴發(fā)生環(huán)境、睡眠影響、持續(xù)時(shí)間、生活工作影響、情緒影響和主觀感覺(jué)評(píng)分均顯著下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的下降程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組耳鳴嚴(yán)重程度積分均顯著下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組耳鳴嚴(yán)重程度積分明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 前列地爾注射液聯(lián)合甲鈷胺片和長(zhǎng)春西汀片治療急性耳鳴具有較好的臨床療效，可改善臨床癥狀，具有一定的臨床推廣應(yīng)用。

Objective To explore the clinical effect of Alprostadil Injection combined with Mecobalamin Tablets and Vinpocetine Tablets in treatment of acute tinnitus. Methods Patients (87 cases) with acute tinnitus in the First Teaching Hospital of Tianjin University of TCM from June 2015 to September 2016 were randomly divided into control group (44 cases) and treatment group (43 cases). Patients in the control group were po administered with Mecobalamin Tablets, 0.5 mg/time, three times daily. And patients in the control group were also po administered with Vinpocetine Tablets, 0.5 mg/time, three times daily. Patients in the treatment group were iv administered with Alprostadil Injection on the basis of the control group, 10 μg added into normal saline 10 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and tinnitus symptoms scores and tinnitus severity scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 61.36% and 86.05%, respectively, and there was difference between two groups (P<0.05). After treatment, the scores of occurrence environment, sleep effect, duration, life influence, emotional impact, and subjective feeling of tinnitus in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the tinnitus severity scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Alprostadil Injection combined with Mecobalamin Tablets and Vinpocetine Tablets has clinical curative effect in treatment of acute tinnitus, can improve clinical symptoms, which has a certain clinical application value.