目的 探討強骨膠囊聯合鹿瓜多肽注射液治療老年原發(fā)性骨質疏松癥的臨床療效。方法 選取2016年3月—2017年3月湖北醫(yī)藥學院附屬人民醫(yī)院（十堰市人民醫(yī)院）收治的老年原發(fā)性骨質疏松癥患者102例，根據用藥的差別分成對照組和治療組，每組各51例。對照組靜脈滴注鹿瓜多肽注射液，10 mL與5%葡萄糖溶液250 mL配伍，1次/d。治療組在對照組基礎上口服強骨膠囊，1粒/次，3次/d。兩組患者均治療4周后進行療效評價。觀察兩組的臨床療效，比較兩組治療前后VAS評分、ODI評分、骨密度（BMD）和血清學相關指標的變化情況。結果 治療后，對照組和治療組總有效率分別為80.39%、96.08%，兩組比較差異具有統(tǒng)計學意義（P< 0.05）。兩組治療后血清轉化生長因子-β1（TGF-β1）、Ⅰ型原膠原N-端前肽（PINP）、骨鈣素（BGP）、骨堿性磷酸酶（ALP）均顯著升高，抗酒石酸酸性磷酸酶（TRACP）水平顯著降低，同組治療前后差異有統(tǒng)計學意義（P< 0.05）；治療后，治療組TGF-β1、PINP、BGP、ALP高于對照組，TRACP水平低于對照組，兩組比較差異具有統(tǒng)計學意義（P< 0.05）。結論 強骨膠囊聯合鹿瓜多肽治療老年原發(fā)性骨質疏松癥具有較好的臨床療效，可有效改善患者疼痛，增加BMD及改善骨代謝指標，具有一定的臨床推廣應用價值。

Objective To investigate the clinical efficacy of Qianggu Capsules combined with Cervus and Cucumis Polypeptide Injection in treatment of senile primary osteoporosis. Methods Patients (102 cases) with senile primary osteoporosis in the Affiliated People's Hospital of Hubei Medical College (Shiyan People's Hospital) from March 2016 to March 2017 were divided into control (51 cases) and treatment (51 cases) groups based on different treatments. Patients in the control group were iv administered with Cervus and Cucumis Polypeptide Injection, 10 mL added into 5% glucose solution 250 mL, once daily. Patients in the treatment group were po administered with Qianggu Capsules on the basis of the control group, 1 grain/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the changes of VAS score, ODI score, bone density (BMD) and blood related indicators in two groups before and after treatment were compared. Results After treatment, After treatment, the clinical efficacies in the control and treatment groups were 80.39% and 96.08%, respectively, and there was difference between two groups (P < 0.05). After treatment, TGF-β1, PINP, BGP, and ALP were significantly increased, but TRACP in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, TGF-β1, PINP, BGP, and ALP in the treatment group were higher than those in the control group, but TRACP in the treatment group were significantly lower than that in the control group, and the difference was statistically significant between two groups (P < 0.05). Conclusion Qianggu Capsules combined with Cervus and Cucumis Polypeptide Injection has clinical curative effect in treatment of senile primary osteoporosis, and can effectively improve pain situation, also can increase BMD and improve bone metabolism indexes, which has a certain clinical application value.