目的 探討金匱腎氣丸聯(lián)合克拉霉素緩釋片治療老年慢性前列腺炎的臨床療效. 方法 選取2015年2月—2016年10月秦皇島市第二醫(yī)院收治的老年慢性前列腺炎患者134例，所有患者均采用隨機數(shù)字表法分成對照組和治療組，每組各67例。對照組口服克拉霉素緩釋片，0.5 g/次，1次/d。治療組在對照組基礎上口服金匱腎氣丸，9 g/次，2次/d。兩組均連續(xù)治療30 d。觀察兩組的臨床療效，比較兩組的美國國立衛(wèi)生院制定的慢性前列腺炎癥狀指數(shù)（NIH-CPSI）評分、白細胞（WBC）計數(shù)和前列腺液分泌型免疫球蛋白A（sIgA）水平。結(jié)果 治療后，對照組和治療組的總有效率分別為76.12%、91.04%，兩組比較差異有統(tǒng)計學意義（P< 0.05）。治療后，兩組疼痛、尿路癥狀、生活質(zhì)量和總評分均顯著下降，同組治療前后比較差異有統(tǒng)計學意義（P< 0.05）；且治療組這些觀察指標明顯低于對照組，兩組比較差異具有統(tǒng)計學意義（P< 0.05）。治療后，兩組WBC計數(shù)均顯著減少，同組治療前后比較差異有統(tǒng)計學意義（P< 0.05）；且治療組WBC計數(shù)明顯低于對照組，兩組比較差異具有統(tǒng)計學意義（P< 0.05）。治療后，兩組sIgA水平均顯著下降，同組治療前后比較差異有統(tǒng)計學意義（P< 0.05）；且治療組sIgA水平明顯低于對照組，兩組比較差異具有統(tǒng)計學意義（P< 0.05）。結(jié)論 金匱腎氣丸聯(lián)合克拉霉素緩釋片治療老年慢性前列腺炎具有較好的臨床療效，可改善臨床癥狀，提高患者的生活質(zhì)量，降低前列腺液sIgA水平，具有一定的臨床推廣應用價值。

Objective To investigate the clinical efficacy of Jinkui Shenqi Pills combined with Clarithromycin Sustained Release Tablets in treatment of senile chronic prostatitis. Methods Patients (134 cases) with senile chronic prostatitis in The Second Hospital of Qinhuangdao from February 2015 to October 2016 were randomly divided into control and treatment groups, and each group had 67 cases. Patients in the control group were po administered with Clarithromycin Sustained Release Tablets, 0.5 g/time, once daily. Patients in the treatment group were po administered with Jinkui Shenqi Pills on the basis of the control group, 9 g/time, twice daily. Patients in two groups were treated for 30 d. After treatment, the clinical efficacies were evaluated, and NIH-CPSI scores, WBC counts, and the sIgA levels in prostatic fluid in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.12% and 91.04%, respectively, and there was difference between two groups (P < 0.05). After treatment, the scores of pain, urinary symptoms, quality of life, and the total score in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the WBC counts in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the sIgA levels in prostatic fluid in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Jinkui Shenqi Pills combined with Clarithromycin Sustained Release Tablets has clinical curative effect in treatment of senile chronic prostatitis, can improve clinical symptoms, increase quality of life, and decrease the sIgA level in prostatic fluid, which has a certain clinical application value.