1H-NMR和MS確證?;钚詼y(cè)試結(jié)果顯示化合物F-2和G-2具有比陽性對(duì)照藥lesinurad還要強(qiáng)的URAT1抑制活性。結(jié)論 設(shè)計(jì)了一條合成目標(biāo)化合物的簡(jiǎn)易路線,該路線操作簡(jiǎn)便、路線短、收率高。目標(biāo)化合物也具有一定的生物活性。;Objective To design and synthesize naphthyl triazole carboxylic acid compounds and study their inhibitory activities against URAT1. Methods 4-Bromomethyl-naphthalene, [1,2,4]triazole-3-thiol, and methyl bromoacetate were used as a starting material to synthesize the target compounds by substitution and hydrolysis reaction. And their URAT1 inhibitory activities were tested. Results Three target compounds were designed and synthesized, and their chemical structures were confirmed by 1H-NMR and MS. Activities test showed that compounds F-2 and G-2 had stronger URAT1 inhibitory activities than positive control drug lesinurad. Conclusion A facile route for synthesis of target compound is developed, which has the advantages of simple operating procedure, easy post-processing, and high-yield. And target compounds have a certain biological activities."/>

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首頁 > 過刊瀏覽>2017年第32卷第7期 >2017,32(7):1165-1170. DOI:10.7501/j.issn.1674-5515.2017.07.001
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萘甲基三唑羧酸類化合物的合成及其抑制URAT1活性的研究

Synthesis of naphthyl triazole carboxylic acid compounds and their inhibitory activities against URAT1

發(fā)布日期:2017-07-27