在腦缺血再灌注損傷的病理過(guò)程中，現(xiàn)有的文獻(xiàn)數(shù)據(jù)表明氧自由基在其中發(fā)揮重要作用，而其來(lái)源有多種途徑。在許多細(xì)胞中，NADPH氧化酶是過(guò)氧化物產(chǎn)生的一個(gè)主要因素，與氧自由基的病理作用關(guān)系密切。NADPH氧化酶2（NOX2）是NADPH氧化酶的一個(gè)亞型，近年研究表明，其過(guò)度表達(dá)與腦缺血再灌注損傷的發(fā)生發(fā)展關(guān)系密切。主要對(duì)NOX2在腦缺血再灌注損傷中的作用機(jī)制進(jìn)行綜述。

Oxygen free radicals generated from different ways play a significant role in the pathogenesis of cerebral ischemia reperfusion injury (CIRI) according to available literatures. As a key factor in the production of peroxides in many cells, NADPH oxidase is closely related to the pathogenesis of oxygen free radicals. Recent studies have shown that the expression of NADPH oxidase 2 (NOX2), a subtype of NADPH oxidase, which plays an important role in the development of CIRI. The mechanism of NOX2 in CIRI is reviewed in this paper.