磷脂酰肌醇3-激酶（PI3K）信號通路是正常細(xì)胞生理代謝的重要信號轉(zhuǎn)導(dǎo)途徑，也是腫瘤細(xì)胞發(fā)生和發(fā)展的關(guān)鍵信號通路。人類腫瘤基因組學(xué)研究表明，PI3K信號通路可將癌基因和多種受體與許多細(xì)胞功能聯(lián)系在一起，該通路也是腫瘤中最常被激活的通路，抑制該信號通路，可抑制腫瘤的生長與轉(zhuǎn)移。概述了PI3K及其信號通路與腫瘤發(fā)生、發(fā)展和轉(zhuǎn)移的關(guān)系以及PI3K信號通路的主要抑制途徑，綜述近年來抗腫瘤天然藥物抑制PI3K信號通路的研究進(jìn)展。

The phosphoinositide 3-kinase (PI3K) signal pathway, an important signal transduction pathway in the normal cell physiological metabolism, is well associated with the occurrence and development of malignancies. The research about human cancer genomics shows that PI3K signaling pathway can link cancer genes and multiple receptors with many cellular functions, and PI3K signaling pathway is the most common activated pathway in cancer. Therefore, inhibition of PI3K signaling pathway will suppress tumor growth and metastasis. In this paper, the relationship between PI3K signaling pathway and the occurrence, development and metastasis of malignancies, and the major inhibitory way against PI3K signaling pathway were outlined. Especially, the research progress on the molecular mechanisms of inhibiting PI3K signaling pathway by anti-tumor natural products was reviewed.

國家自然科學(xué)基金資助項(xiàng)目（21372156）；遼寧省自然科學(xué)基金資助項(xiàng)目（2015020687）