目的 討論喜炎平注射液聯(lián)合注射用磷酸肌酸鈉治療小兒病毒性心肌炎的療效及其安全性。方法 選取天津市泰達(dá)醫(yī)院2014年6月—2016年6月收治的病毒性心肌炎患兒78例，隨機(jī)分為對照組（36例）和治療組（42例）。對照組靜脈滴注注射用磷酸肌酸鈉，1 g溶于5%葡萄糖注射液100 mL中后30～45 min給藥，1次/d。治療組在對照組基礎(chǔ)上靜脈滴注喜炎平注射液，5～10 mg/kg（0.2～0.4 mL/kg）加入5%葡萄糖注射液或0.9%氯化鈉注射液100～250 mL中，1次/d。兩組患兒均連續(xù)給藥14 d。觀察兩組的臨床療效，比較治療前后兩組心肌學(xué)指標(biāo)和心肌鈣蛋白（cTnI）改善情況。結(jié)果 治療后，對照組、治療組總有效率分別為83.3%、96.6%，兩組總有效率比較差異具有統(tǒng)計(jì)學(xué)意義（P< 0.05）。治療后，兩組血清磷酸肌酸激酶（CK）、磷酸肌酸激酶同工酶（CK-MB）、天冬氨酸氨基轉(zhuǎn)移酶（AST）、乳酸脫氫酶（LDH）、心肌鈣蛋白（cTnI）水平均顯著降低，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P< 0.05）；且治療組各指標(biāo)明顯低于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P< 0.05）。治療過程中治療組和對照組患者均未出現(xiàn)明顯的不良反應(yīng)。結(jié)論 喜炎平注射液聯(lián)合磷酸肌酸鈉注射液治療小兒病毒性心肌炎具有較好的臨床療效，能夠明顯改善心肌學(xué)指標(biāo)和心肌鈣蛋白，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To discuss the curative effect of Xiyanping Injection combined with Creatine Phosphate Sodium for injection in treatment of viral myocarditis in children and its safety. Methods Children (78cases) with viral myocarditis in Tianjin TEDA Hospital from June 2014 to June 2016 were randomly divided into control group (36 cases) and treatment group (42 cases). Children in the control group in the control group were iv administered with Creatine Phosphate Sodium for injection, 1 g added into 5% Glucose Solution 100 mL, then administered before 30-45 min, once daily. Patients in the treatment group were iv administered with Xiyanping Injection, 5-10 mg/kg (0.2-0.4 mL/kg) added into 5% Glucose Solution or normal saline 100-250 mL, once daily. Children in two groups were treated for 14 d. After treatment, the efficacy was evaluated, and myocardial markers and cardiac troponin (cTnI) were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 83.3% and 96.6%, respectively, and there was difference between two groups (P < 0.05). After treatment, serum CK, CK-MB AST, LDH and cTnI levels in two groups were significantly decreased, and the differences were statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). There were no obvious adverse reactions in two groups. Conclusion Xiyanping Injection combined with Creatine Phosphate Sodium for injection has clinical curative effect in the treatment of viral myocarditis, can improve myocardial marker and cTnI, and have no obvious adverse reactions, which has a certain clinical application value.