目的 探究仙靈骨葆膠囊聯(lián)合唑來膦酸治療骨質疏松性椎體壓縮性骨折的療效。方法 選取2014年1月—2016年1月天津中醫(yī)藥大學第一附屬醫(yī)院收治的骨質疏松性椎體壓縮性骨折行經(jīng)皮椎體成形術的112例患者，隨機分為對照組和治療組，每組各56例。兩組均行經(jīng)皮椎體成形術，對照組術后第3天靜脈滴注唑來膦酸注射液，5 mg/次，1次/年。治療組患者在對照組的治療基礎上口服仙靈骨葆膠囊，3粒/次，2次/d，3個月為一個療程，共服用2個療程。觀察兩組的臨床療效，同時比較治療前，治療3、6個月時腰椎、股骨前端的骨密度、VAS評分和PINP水平的變化情況，比較兩組治療前后椎體后凸Cobb角及其恢復率。結果 治療后，對照組和治療組的總有效率分別為82.14%、96.43%，兩組比較差異有統(tǒng)計學意義（P < 0.05）。治療后，兩組患者腰椎、股骨前端骨密度均明顯提高，VAS評分和PINP水平均明顯降低，同組治療前后差異有統(tǒng)計學意義（P < 0.05）；治療后，治療組患者腰椎、股骨前端骨密度高于對照組，治療組VAS評分和PINP水平低于對照組，兩組比較差異具有統(tǒng)計學意義（P < 0.05）。治療后，兩組椎體后凸Cobb角均較治療前顯著降低，同組治療前后差異有統(tǒng)計學意義（P < 0.05）；治療后治療組椎體后凸Cobb角低于對照組，兩組比較差異具有統(tǒng)計學意義（P < 0.05）。治療后，治療組椎體后凸Cobb角恢復率明顯高于對照組，兩組比較差異具有統(tǒng)計學意義（P < 0.05）。結論 仙靈骨葆膠囊聯(lián)合唑來膦酸治療骨質疏松性壓縮性骨折具有較好的臨床療效，可增加患者骨密度，有效減輕患者疼痛感，促進椎體壓縮性骨折的愈合，具有一定的臨床推廣應用價值。

Objective To investigate the clinical effect of Xianling Gubao Capsule combined with zoledronic acid in treatment of osteoporotic vertebral compression fractures. Methods Patients (112 cases) with osteoporotic vertebral compression fractures in First Teaching Hospital of Tianjin University of TCM from January 2014 to January 2016 were divided into control (56 cases) and treatment (56 cases) groups based on different treatments. Both groups were given vertebral plasty. Patients in the control group were iv administered with Zoledronic acid Injection after surgery for 3 d, 5 mg/time, once a year. Patients in the treatment group were po administered with Xianling Gubao Capsules on the basis of the control group, three grains/time, twice daily. Three months were as one treatment course, and they were treated for two courses. After treatment, the clinical efficacy was evaluated, and bone density of lumbar spine, femoral front-end, VAS score, and PINP levels before treatment, three and six months of treatment in two groups were compared. The vertebral convex Cobb Angle and its recovery rates in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.14% and 96.43%, respectively, and there was difference between two groups (P < 0.05). After treatment, bone density of lumbar spine and femoral front-end in two groups were significantly increased, but VAS score and PINP levels were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, bone density of lumbar spine and femoral front-end in the treatment group were higher than those in the control group, and VAS score and PINP levels were lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the vertebral convex Cobb Angle in two groups significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the vertebral convex Cobb Angle in the treatment group was lower than that in the control group, with significant difference between two groups (P < 0.05). After treatment, the recovery rate of vertebral convex Cobb Angle was higher than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Xianling Gubao Capsule combined with zoledronic acid has a obvious clinical effect in treatment of osteoporotic vertebral compression fractures, and it can increase bone density, alleviate pain effectively, also can promote the healing of vertebral compression fractures, which has a certain clinical application value.