目的 了解解放軍總醫(yī)院海南分院質(zhì)子泵抑制劑（PPIs）的使用情況，為合理使用和管理提供參考。方法 收集解放軍總醫(yī)院海南分院2013-2015年P(guān)PIs的相關(guān)使用數(shù)據(jù)，并分析其變化趨勢(shì)。結(jié)果 PPIs的用藥金額及其占總用藥金額的比例均逐年增長(zhǎng)；PPIs用藥金額排前3位科室分別為消化內(nèi)科、急診科和腫瘤科；門診和住院PPIs用藥金額及使用率均逐年增長(zhǎng)；口服劑型PPIs用藥金額逐年增長(zhǎng)，但構(gòu)成比逐年下降，而注射劑型PPIs用藥金額及構(gòu)成比均逐年增長(zhǎng)；注射用蘭索拉唑、注射用埃索美拉唑鈉的DDDs、用藥金額和構(gòu)成比均逐年增長(zhǎng)，而注射用泮托拉唑鈉和注射用奧美拉唑鈉DDDs、用藥金額和構(gòu)成比均逐年下降。結(jié)論 解放軍總醫(yī)院海南分院絕大部分PPIs的用藥金額和使用率均呈持續(xù)上升趨勢(shì)，應(yīng)及時(shí)把握用藥現(xiàn)狀，規(guī)范合理用藥。

Objective To investigate the use of proton pump inhibitors (PPIs) in Hainan Branch of PLA General Hospital, so as to provide reference for the rational use and better management of PPIs. Methods The data of the clinical use of PPIs were collected in Hainan Branch of PLA General Hospital from 2013 to 2015, and then the change trend of the application of PPIs was analyzed. Results The consumption sum of PPIs and the ratio to total cost of drugs raised year by year. The top 3 departments of PPIs cost were Department of Digestive, Emergency, and Oncology. The consumption sum and the usage rate of PPIs for inpatients and outpatients were increased year by year. The cost of PPIs for oral was increased, but the proportion was decreased yearly. While both the cost and proportion of PPIs for injection were increased yearly. DDDs, consumption sum and the constituent ratio of Lansoprazole for injection and Esomeprazole Sodium for injection were increased yearly. However, those of Pantoprazole Sodium for injection and Omeprazole Sodium for injection were reduced yearly. Conclusion The consumption sum and usage rate of most PPIs in Hainan Branch of PLA General Hospital both show a trend of rising, therefore current situation of drug application should be grasped timely, in order to standardize the rational use of drugs.