目的 探討硝呋太爾膠囊聯(lián)合鹽酸環(huán)丙沙星栓治療細菌性陰道炎的臨床療效。方法 選取2014年4月-2016年4月在樂東黎族自治縣第二人民醫(yī)院接受診治的細菌性陰道炎患者84例，按照治療方法的差別分成對照組和治療組，每組各42例。對照組睡前清潔外陰后給予鹽酸環(huán)丙沙星栓，1粒放置陰道深部，1次/d。治療組在對照組基礎(chǔ)上口服硝呋太爾膠囊，2粒/次，3次/d。兩組患者均治療14 d。觀察兩組的臨床療效，比較兩組的臨床癥狀消失時間、陰道灌洗液炎性因子和血清氧化應(yīng)激產(chǎn)物情況。結(jié)果 治療后，對照組和治療組的總有效率分別為80.95%、95.24%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，治療組白帶減少時間、外陰瘙癢消失時間、外陰陰道疼痛消失時間、黏膜充血消失時間均較對照組明顯縮短，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組陰道灌洗液中白細胞介素-2（IL-2）、白細胞介素-8（IL-8）和白細胞介素-13（IL-13）水平均顯著降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些觀察指標的下降程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組血清丙二醛（MDA）和內(nèi)皮素-1（ET-1）水平均顯著降低，而超氧化物歧化酶（SOD）和一氧化氮（NO）水平均顯著升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些觀察指標的改善程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 硝呋太爾膠囊聯(lián)合鹽酸環(huán)丙沙星栓治療細菌性陰道炎具有較好的臨床療效，可明顯改善臨床癥狀，降低炎性因子和氧化應(yīng)激產(chǎn)物水平，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Nifuratel Capsules combined with Ciprofloxacin Hydrochloride Suppositories in treatment of bacterial vaginitis. Methods Patients (84 cases) with bacterial vaginitis in the Second People's Hospital of Ledong Li Nationality Autonomous County from April 2014 to April 2016 were enrolled in this study. According to the difference treatment plan, patients were randomly divided into control and treatment groups, and each group had 42 cases. Patients in the control group were given Ciprofloxacin Hydrochloride Suppositories after cleaning the vulva before bedtime, 1 grain placed into the vagina deep, once daily. Patients in the treatment group were po administered with Nifuratel Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and clinical symptom disappearance time, vaginal lavage fluid inflammatory factors, and serum oxidative stress products in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.95% and 95.24%, respectively, and there was difference between two groups (P<0.05). After treatment, the disappeared times of leucorrhea reduced, genital itching, vaginal pain, and mucosal congestion in the treatment group were shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of IL-2, IL-8, and IL-13 in vaginal lavage fluid in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of MDA and ET-1 in two groups were significantly decreased, but the levels of SOD and NO in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Nifuratel Capsules combined with Ciprofloxacin Hydrochloride Suppositories has clinical curative effect in treatment of bacterial vaginitis, can improve clinical symptoms, and decrease the levels of inflammatory factors and oxidative stress products, which has a certain clinical application value.