目的 探討膽寧片聯(lián)合多烯磷脂酰膽堿膠囊治療非酒精性脂肪肝的臨床療效。方法 收集2015年4月-2016年4月在上海楊浦區(qū)五角場街道社區(qū)衛(wèi)生服務(wù)中心進(jìn)行治療的非酒精性脂肪肝病患者88例，隨機(jī)分為對照組（44例）和治療組（44例）。對照組口服多烯磷脂酰膽堿膠囊，2粒/次，3次/d。治療組在對照組的基礎(chǔ)上口服膽寧片，5片/次，3次/d。兩組患者均連續(xù)治療6個月。評價兩組患者臨床療效，同時比較兩組治療前后血脂水平和肝功能改變。結(jié)果 治療后，對照組和治療組總有效率分別為81.82%、97.73%，兩組總有效率比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者三酰甘油（TG）、總膽固醇（TC）、低密度脂蛋白（LDL-C）水平均顯著降低，而高密度脂蛋白（HDL-C）則明顯升高，同組治療前后比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組患者上述血脂水平改善程度優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者丙氨酸氨基轉(zhuǎn)移酶（ALT）、天冬氨酸氨基轉(zhuǎn)移酶（AST）和γ-谷氨酰轉(zhuǎn)移酶（γ-GT）水平均比同組治療前顯著降低，同組比較差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組患者肝功能改善程度顯著優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 膽寧片聯(lián)合多烯磷脂酰膽堿膠囊治療非酒精性脂肪肝效果顯著，可明顯降低患者血脂水平，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Danning Tablets combined with Polyene Phosphatidylcholine Capsules in treatment of nonalcoholic fatty liver disease. Methods Patients (88 cases) with nonalcoholic fatty liver disease in Shanghai Yangpu District Wujiaochang Street Community Health Service Center from April 2015 to April 2016 were randomly divided into control (44 cases) and treatment (44 cases) groups. Patients in the control group were po administered with Polyene Phosphatidylcholine Capsules, 2 grains/time, three times daily. Patients in the treatment group were po administered with Danning Tablets on the basis of the control group, 5 tablets/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacy was evaluated, and blood lipid level and liver function in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.82% and 97.73%, respectively, and there was difference between two groups (P<0.05). After treatment, TG, TC, and LDL-C levels in two groups were significantly decreased, but HDL-C was significantly increased, and the difference was statistically significant in the same group (P<0.05). And the blood lipid level in the treatment group was significantly better than that in the control group, with significant difference between two groups (P<0.05). After treatment, ALT, AST, and γ-GT levels in two groups were significantly decreased, and there was difference in the same group (P<0.05). And the improvement degree of liver function in the treatment group was significantly better than that in the control group, with significant difference between two groups (P<0.05). Conclusion Danning Tablets combined with Polyene Phosphatidylcholine Capsules has significant effect in treatment of nonalcoholic fatty liver disease, and can significantly reduce the blood lipid level, which has a certain clinical application value.