目的 觀察安神補(bǔ)腦液聯(lián)合舍曲林治療腦梗死后睡眠障礙的臨床療效。方法 選取2015年7月-2016年6月重慶市開州區(qū)人民醫(yī)院收治的112例腦梗死后睡眠障礙患者隨機(jī)分為對(duì)照組和治療組，每組各56例。對(duì)照組患者口服鹽酸舍曲林片，1片/次；治療組在對(duì)照組治療基礎(chǔ)上口服安神補(bǔ)腦液，10 mL/次，2次/d。兩組療程均為4周。觀察兩組的臨床療效，比較兩組治療前后匹茲堡睡眠質(zhì)量指數(shù)（PSQI）、阿森斯失眠量表（AIS）評(píng)分、美國國立衛(wèi)生研究院卒中量表（NIHSS）評(píng)分、漢密爾頓抑郁量表（HAMD）評(píng)分，睡眠狀況相關(guān)指標(biāo)。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為71.43%、91.07%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組PSQI評(píng)分、AIS評(píng)分、NIHSS評(píng)分、HAMD評(píng)分均顯著降低，同組治療前后差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，治療組PSQI評(píng)分、AIS評(píng)分、NIHSS評(píng)分、HAMD評(píng)分低于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組睡眠總時(shí)間、睡眠效率均較治療前顯著提高，夜間覺醒次數(shù)減少，同組治療前后差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，治療組睡眠總時(shí)間、睡眠效率高于對(duì)照組，夜間覺醒次數(shù)少于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 安神補(bǔ)腦液聯(lián)合舍曲林治療腦梗死后睡眠障礙，臨床療效確切，患者睡眠質(zhì)量改善明顯，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To observe the clinical effect of Anshen Bunao Liquid combined with sertraline in treatment of sleep disorder after stroke. Methods Patients (112 cases) with sleep disorder after stroke in Kaizhou District People's Hospital of Chongqing City from July 2015 to June 2016 were randomly divided into control and treatment groups, and each group had 56 cases. Patients in the control group were po administered with Sertraline Hydrochloride Tablets, 1 tablet/time. Patients in the treatment group were po administered with Anshen Bunao Liquid on the basis of the control group, 10 mL/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the efficacy was evaluated, and the scores of PSQI, AIS, NIHSS, and HAMD, and sleep related indicators before and after treatment in two groups were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 71.43% and 91.07%, respectively, and there were differences between two groups (P<0.05). After treatment, PSQI score, AIS score, NIHSS score, and HAMD score in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, PSQI score, AIS score, NIHSS score, and HAMD score in the treatment group were lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the total sleep time and sleep efficiency were significantly higher than those in the same group before treatment, and wake up times at night were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the total sleep time and sleep efficiency in the treatment were higher than those in the control group, and wake up times at night were less than those in the control group, and there were differences between two groups (P<0.05). Conclusion Anshen Bunao Liquid combined with sertraline has clinical curative effect in treatment of sleep disorder after stroke, and can improve sleep quality obviously, which has a certain clinical application value.