目的 觀(guān)察天麻鉤藤顆粒聯(lián)合左旋多巴治療帕金森病的臨床療效。方法 選取2015年7月-2016年6月監(jiān)利縣人民醫(yī)院收治的帕金森患者88例，隨機(jī)分為對(duì)照組和治療組，每組各44例。對(duì)照組口服左旋多巴片，125 mg/次，2次/d，每周調(diào)整藥物用量，逐漸增量至250 mg/次，3次/d，每日總劑量不超過(guò)6 g；治療組在對(duì)照組的基礎(chǔ)上口服天麻鉤藤顆粒，5 g/次，3次/d。兩組均治療3個(gè)月。治療后，觀(guān)察兩組的臨床療效，比較兩組日常生活能力和運(yùn)動(dòng)能力評(píng)分和不良反應(yīng)情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為61.36%、72.27%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組日常生活能力和運(yùn)動(dòng)能力評(píng)分均顯著下降，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些評(píng)分明顯低于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組不良反應(yīng)發(fā)生率比較差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論 天麻鉤藤顆粒聯(lián)合左旋多巴治療帕金森病，臨床療效確切，癥狀改善明顯，值得臨床推廣。

Objective To observe the clinical effect of Tianma Gouteng Granules combined with levodopa in treatment of Parkinson's disease. Methods Patients (88 cases) with Parkinson's disease in Jianli People's Hospital from July 2015 to June 2016 were randomly divided into control and treatment groups, and each group had 44 cases. Patients in the control group were po administered with Levodopa Tablets, 125 mg/time, twice daily. The dosage was adjusted every week, and was increased to 250 mg/time, three times daily. The total dosage was not more than 6 g/d. Patients in the treatment group were po administered with Tianma Gouteng Granules on the basis of the control group, 5 g/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and daily life ability and movement ability scores, and adverse reactions in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 61.36% and 72.27%, respectively, and there was difference between two groups (P<0.05). After treatment, daily life ability and movement ability scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And these scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). There was no significant difference in adverse reactions between two groups. Conclusion Tianma Gouteng Granules combined with levodopa has clinical curative effect in treatment of Parkinson's disease, and can improve symptoms significantly, which has a certain clinical application value.