目的 分析2013-2016年鄭州市婦幼保健院婦科清潔手術(shù)預防用抗菌藥物的使用情況，為進一步規(guī)范抗菌藥物合理應用提供參考。方法 對2013年1月-2016年2月婦科清潔手術(shù)預防用抗菌藥物的使用情況進行回顧性調(diào)查，并評價其合理性。結(jié)果 1 560例患者中，780例預防用抗菌藥物，抗菌藥物使用率為50.0%。用藥維持時間以48、72 h為主，構(gòu)成比分別為50.0%、39.5%。共涉及9個品種，頭孢呋辛、甲硝唑和頭孢西丁使用頻次居前3位。術(shù)前0.5~1.0 h給藥的例數(shù)最多，構(gòu)成比為77.3%。不合理用藥表現(xiàn)形式主要有用藥指征把握不嚴（31.4%）、用藥維持時間長（28.7%）、品種選擇不當（17.6%）等。結(jié)論 鄭州市婦幼保健院婦科清潔手術(shù)預防用抗菌藥物使用基本合理，但仍存在不合理用藥現(xiàn)象，應加強監(jiān)督管理。

Objective To evaluate the use of antibacterial drugs in gynecological aseptic operations in Women and Infants Hospital of Zhengzhou from 2013 to 2016, and to provide reference for the further application of antibacterial drugs. Methods The use of prophylactic antibacterial drugs in gynecological aseptic operations in Women and Infants Hospital of Zhengzhou from January 2013 to February 2016 were analyzed statistically, and the rationality was evaluated. Results There were 780 cases of patients using prophylactic antibacterial drugs in 1 560 patients, and the usage rate of antibacterial drugs was 50.0%. The main medication maintaining time of antibacterial drugs were 48 and 72 h, accounting for 50.0% and 39.5%, respectively. There were nine breeds, in which cefuroxime, metronidazole, and cefoxitin were ranked the top three. The most time administration of antibacterial drugs was 0.5-1.0 h, accounting for 77.3%. The main types of unreasonable medicine were the non-strict mastering indications of the medication indication (31.4%), prolonged medication duration (28.7%), and inappropriate choice of medicine (17.6%). Conclusion The use of prophylactic antibacterial drugs in gynecological aseptic operations in Women and Infants Hospital of Zhengzhou is basically rational. But there are still some irrational usages of antibacterial drugs, and they needs further efforts to strengthen the management.

常州四藥臨床藥學科研基金項目（CZSYJJ15018）