目的 研究南京地區(qū)34家醫(yī)院2013-2015年口服抗消化潰瘍藥物的使用情況及發(fā)展趨勢。方法 對2013-2015年南京地區(qū)34家醫(yī)院口服抗消化潰瘍藥物的用藥金額、用藥頻度（DDDs）、日均費用（DDC）及藥品排序比（B/A）等進行統(tǒng)計分析。結(jié)果 口服抗消化潰瘍藥品的用藥金額和DDDs逐年增長，質(zhì)子泵抑制劑逐年增長，胃黏膜保護藥增長迅速，抗酸藥增長緩慢。雷貝拉唑3年的用藥金額均居首位，DDDs排名前2位的是奧美拉唑和蘭索拉唑。質(zhì)子泵抑制劑中，DDC最高的是艾司奧美拉唑，其次是雷貝拉唑鈉。將近一半藥品的B/A基本接近于1，表明大多數(shù)藥物同步性較好。結(jié)論 質(zhì)子泵抑制劑是治療消化性潰瘍的首選藥物，胃黏膜保護藥發(fā)展迅速，前景廣闊。

Objective To evaluate the utilization and tendency of oral antiseptic ulcer drugs in 34 hospitals from Nanjing area during 2013-2015. Methods Consumption sum, defined daily doses (DDDs), defined daily cost (DDC) and drug sequence ratio (B/A) in 34 hospitals from Nanjing area during 2013-2015were analyzed statistically. Results Consumption sum and DDDs of oral antiseptic ulcer drugs were increased year by year. Consumption sum and DDDs of proton pump inhibitor were increased year by year. Gastric mucosal protective drugs showed a rapid upward trend. While consumption sum and DDDs of antacids showed a slow growth. Consumption sum of rabeprazole ranked first for three years, and the top two were omeprazole and lansoprazole in respect of DDDs. In proton pump inhibitor, DDC of esomeprazole was the highest, and then was rabeprazole sodium. B/A of almost half of the drugs closed to 1.00, indicating that the synchronism was better. Conclusion Proton pump inhibitors are used as the first choice for peptic ulcer. Gastric mucosal protective drugs grow quickly and there exists broad prospects.

江蘇高校優(yōu)勢學(xué)科建設(shè)工程資助項目