目的 觀察雷尼替丁聯(lián)合西地碘含片治療復(fù)發(fā)性阿弗他潰瘍的臨床療效。方法 選取2013年8月-2015年7月羅田縣萬密齋醫(yī)院口腔科收治的復(fù)發(fā)性阿弗他潰瘍患者124例，按照入選次序編號并分為對照組和治療組，每組各62例。對照組口含西地碘含片，1片/次，5次/d。治療組在對照組治療的基礎(chǔ)上，取鹽酸雷尼替丁膠囊研磨成粉末，用消毒棉簽將其涂敷于潰瘍面上，1粒/次，4次/d，直至潰瘍消失，黏膜修復(fù)完全為止。觀察兩組的臨床療效，同時比較兩組患者疼痛指數(shù)和平均潰瘍期。結(jié)果 治療后，對照組和治療組的總有效率分別為80.65%、95.16%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者疼痛指數(shù)均較治療前顯著降低，同組治療前后差異有統(tǒng)計學(xué)意義（P<0.05）；治療后治療組疼痛指數(shù)低于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療組患者的平均潰瘍期短于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 雷尼替丁聯(lián)合西地碘含片治療口腔潰瘍具有較好的臨床療效，可降低疼痛指數(shù)，縮短平均潰瘍期，具有一定的臨床推廣應(yīng)用價值。

Objective To explore the clinical efficacy of ranitidine combined with Cydiodine Buccal Tablets in treatment of recurrent aphthous ulcer. Methods The total of 124 patients with recurrent aphthous ulcer in Wanmizhai Hospital in Luotian County from August 2013 to July 2015 were analyzed. The patients were divided into control group and treatment group according to the selected order numbers, and each group had 62 cases. The patients in the control group held Cydiodine Buccal Tablets in the mouth, 1 tablet/time, five times daily. Ranitidine Hydrochloride Capsules were grounded into powder, and coated on the ulcer surface with disinfection swab in the treatment group on the basis of the control group, 1 grain/time, four times daily. Two groups were treated until ulcer disappeared and mucosal repaired completely. After treatment, the efficacy was evaluated, and pain indexes and average ulcer stage in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 80.65% and 95.16%, respectively, and there were differences between two groups (P<0.05). After treatment, pain indexes in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, pain indexes in the treatment group were lower than that in the control group, with significant difference between two groups (P<0.05). The average ulcer stage in the treatment group was shorter than that in the control group, with significant difference between two groups (P<0.05). Conclusion Ranitidine combined with Cydiodine Buccal Tablets has clinical curative effect in treatment of recurrent aphthous ulcer, and can reduce the pain index, also can shorten the average ulcer stage, which has a certain clinical application value.