目的 制備丹酚酸B脂化乳，并考察其在人工胃腸液中的穩(wěn)定性。方法 制備丹酚酸B脂化乳粒、脂化乳。采用紫外分光光度法測定并比較脂化乳粒、脂化乳中丹酚酸B在人工胃液和人工腸液中的變化。結(jié)果 不同制劑中丹酚酸B在人工胃液中的量均有所降低，但脂化乳和脂化乳粒均較水溶液中丹酚酸B的量高，3 h后丹酚酸B水溶液中藥物的量分別較脂化乳、脂化乳粒少19.3%、6.4%。不同制劑中丹酚酸B在人工腸液中的量均有所降低，但脂化乳、脂化乳粒均較水溶液中丹酚酸B的量高，6 h后丹酚酸B水溶液中藥物的量分別較脂化乳、脂化乳粒少32.7%、5.3%。結(jié)論 丹酚酸B脂化乳、脂化乳粒均能提高人工胃、腸液中所包載藥物的穩(wěn)定性；且脂化乳效果優(yōu)于脂化乳粒。

Objective To prepare Salvianolic Acid B Lipo-emul, and study stability of salvanolic acid B in artificial gastrointestinal fluid. Methods Salvianolic Acid B Lipo-emul and Lipo-emul Particles were prepared. UV spectrophotometry was used to determine concentration of salvanolic acid B in different preparations. Concentration changes of salvanolic acid B in different preparations in artificial gastrointestinal fluid were compared. Results The contents of salvianolic acid B of different preparations in artificial gastric juice were decreased, but the index in lipo-emul and lipo-emul particle was higher than those in solution. In artificial gastric juice, salvanolic acid B content in solution was 19.3% and 6.4% less than lipo-emul and lipo-emul particle after 3 h. The contents of salvianolic acid B of different preparations in artificial intestinal juice were also decreased, and salvianolic acid B content in solution was 32.7% and 5.3% less than lipo-emul and lipo-emul particle after 6 h. Conclusion Salvianolic Acid B Lipo-emul and Lipo-emul Particles can improve the loaded-drugs' stability in the artificial gastrointestinal fluid. And Lipo-Emul's stability is better than Lipo-Emul particle's.

北京市自然科學(xué)基金資助項(xiàng)目（7132118）