目的 探討玉泉顆粒聯(lián)合沙格列汀和二甲雙胍治療2型糖尿病的臨床療效。方法 選取2015年5月-2016年5月在廣州市花都區(qū)人民醫(yī)院接受治療的2型糖尿病患者68例，按照治療方法的差別分為對(duì)照組和治療組，每組各34例。對(duì)照組口服鹽酸二甲雙胍片，1片/次，2次/d；且口服沙格列汀片，1片/次，1次/d。治療組在對(duì)照組基礎(chǔ)上口服玉泉顆粒，1袋/次，4次/d。兩組患者均治療12周。觀察兩組的臨床療效，比較兩組血脂水平、血糖水平、穩(wěn)態(tài)模型評(píng)估胰島素分泌指數(shù)（HOMA-β）和穩(wěn)態(tài)模型評(píng)估胰島素抵抗指數(shù)（HOMA-IR）的情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為88.24%、94.12%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組甘油三酯（TG）、總膽固醇（TC）和低密度脂蛋白膽固醇（LDL-C）水平均明顯降低，而高密度脂蛋白膽固醇（HDL-C）水平均明顯升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組空腹血糖（FBG）、餐后2 h血糖（2 h PG）和糖化血紅蛋白（HbA1c）水平均明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的下降程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組HOMA-β均顯著升高，而HOMA-IR均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 玉泉顆粒聯(lián)合沙格列汀和二甲雙胍治療2型糖尿病具有較好的臨床療效，可明顯改善胰島素抵抗，提高胰島素敏感性，調(diào)節(jié)血脂水平，具有一定臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Yuquan Granules combined Saxagliptin Tablets and Metformin Hydrochloride Tablets in treatment of type 2 diabetes mellitus. Methods Patients (68 cases) with type 2 diabetes mellitus in Huadu District People's Hospital of Guangzhou from May 2015 to May 2016 were enrolled in this study. According to the difference treatment plan, patients were divided into control and treatment groups, and each group had 34 cases. Patients in the control group were po administered with Metformin Hydrochloride Tablets, 1 tablet/time, twice daily. And patients in the control group were also po administered with Saxagliptin Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Yuquan Granules on the basis of the control group, 1 bag/time, four times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and blood lipid level, blood glucose level, HOMA-β, and HOMA-IR in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 88.24% and 94.12%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of TG, TC, and LDL-C in two groups were significantly decreased, but the levels of HDL-C in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of FBG, 2 h PG, and HbA1c in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the HOMA-β in two groups were significantly increased, but the HOMA-IR in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Yuquan Granules combined Saxagliptin Tablets and Metformin Hydrochloride Tablets has clinical curative effect in treatment of type 2 diabetes mellitus, can improve insulin resistance, increase insulin sensitivity, and regulate lipid level, which has a certain clinical application value.