目的 探討知柏地黃丸聯(lián)合醋酸亮丙瑞林治療兒童中樞性性早熟的臨床療效。方法 選取2014年10月-2015年10月在綿陽市中心醫(yī)院治療的兒童中樞性性早熟患兒86例，根據(jù)治療方案的不同分為對(duì)照組（43例）和治療組（43例）。對(duì)照組患兒皮下注射注射用醋酸亮丙瑞林微球，1次/5周，初始劑量為90 μg/kg，連續(xù)用藥3個(gè)月后根據(jù)治療反應(yīng)將劑量調(diào)整為60～80 μg/kg。治療組在對(duì)照組的基礎(chǔ)上口服知柏地黃丸，6 g/次，2次/d。兩組患者均連續(xù)治療6個(gè)月。評(píng)價(jià)兩組患者臨床療效，同時(shí)比較兩組患兒子宮體積、卵巢體積，骨齡指數(shù)和性激素水平變化。結(jié)果 治療后，對(duì)照組和治療組總有效率分別為81.40%、97.67%，兩組總有效率比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患兒的子宮體積、卵巢體積，骨齡指數(shù)均明顯降低，同組治療前后差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組上述臨床指標(biāo)比對(duì)照組更低，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患兒性激素水平明顯降低，同組治療前后差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組的性激素水平顯著優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 知柏地黃丸聯(lián)合醋酸亮丙瑞林治療兒童中樞性性早熟效果顯著，能夠有效改善機(jī)體性激素水平，延遲發(fā)育時(shí)間，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Zhibai Dihuang Pills combined with leuprolide acetate in treatment of children central precocious puberty. Methods Children (86 cases) with central precocious puberty in Mianyang Central Hospital from October 2014 to October 2015 were divided into the control (43 cases) and treatment (43 cases) groups according to different treatment. Children in the control group were iv administered with Leuprorelin Acetate Microspheres for injection, once every 5 weeks, the initial dosage was 90 μg/kg, and then adjusted to 60-80 μg/kg after 3 months according to treatment-response. Children in the treatment group were po administered with Zhibai Dihuang Pills on the basis of the control group, 6 g/time, twice daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacy was evaluated, and the change of uterus size, ovarian size, bone age index and sex hormone levels in two groups was compared. Results After treatment, the clinical efficacy in the control and treatment group was 81.40% and 97.67%, respectively, and there were differences between two groups (P<0.05). After treatment, uterus size, ovarian size, bone age index in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And these indicators in the treatment group were lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, sex hormone level in two groups was significantly decreased, and there were differences between two groups (P<0.05). And the sex hormone level in the treatment group was better than that in the control group, with significant difference between two groups (P<0.05). Conclusion Zhibai Dihuang Pills combined with leuprolide acetate has a significant clinical effect in treatment of children central precocious puberty, can effectively improve hormone level and delayed the development time, which has a certain clinical application value.