目的 探討丹參酮膠囊聯(lián)合奧硝唑治療口腔頜面部炎癥的臨床療效。方法 選取2015年2月-2016年2月在榆林市第一醫(yī)院接受治療的口腔頜面部炎癥患者94例，隨機(jī)分組法分為對照組和治療組，每組各47例。對照組口服奧硝唑片，2片/次，2次/d。治療組在對照組基礎(chǔ)上口服丹參酮膠囊，4粒/次，3次/d。兩組患者均治療5 d。觀察兩組的臨床療效，比較兩組的血液流變學(xué)和血清炎性因子的情況。結(jié)果 治療后，對照組和治療組的總有效率分別為82.98%、95.74%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組紅細(xì)胞沉降率（ESR）、全血黏度、纖維蛋白原（FIB）、血漿黏度均顯著降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的降低程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組C反應(yīng)蛋白（CRP）、白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-γ（TNF-γ）水平均顯著降低，而白細(xì)胞介素-4（IL-4）水平明顯升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 丹參酮膠囊聯(lián)合奧硝唑治療口腔頜面部炎癥具有較好的臨床療效，可改善血液流變學(xué)，降低機(jī)體炎癥性反應(yīng)，具有一定的臨床推廣應(yīng)用價值。

Objective To explore the clinical effect of Danshentong Capsules combined with ornidazole in treatment of oral and maxillofacial inflammation. Methods Patients (94 cases) with oral and maxillofacial inflammation in the First Hospital of Yulin from February 2015 to February 2016 were randomly divided into the control and treatment groups, and each group had 47 cases. Patients in the control group were po administered with Ornidazole Tablets, 2 tablets/time, twice daily. Patients in the treatment group were po administered with Danshentong Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 5 d. After treatment, the clinical efficacies were evaluated, and hemorheology and serum inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 82.98% and 95.74%, respectively, and there was difference between two groups (P<0.05). After treatment, ESR, whole blood viscosity, FIB, and plasma viscosity in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of CRP, IL-6, and TNF-γ in two groups were significantly decreased, but the levels of IL-4 in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Danshentong Capsules combined with ornidazole has clinical curative effect in treatment of oral and maxillofacial inflammation, and can improve hemorheology, decrease inflammatory reactions, which has a certain clinical application value.