目的 探討血府逐瘀膠囊聯(lián)合腦苷肌肽治療血管性癡呆的臨床療效。方法 選取2012年1月-2014年12月衡水市第二人民醫(yī)院收治的血管性癡呆患者220例，隨機(jī)分為對(duì)照組和治療組，每組各110例。對(duì)照組靜脈滴注腦苷肌肽注射液，10 mL/次加生理鹽水250 mL，1次/d。治療組在對(duì)照組的治療基礎(chǔ)上口服血府逐瘀膠囊，6粒/次，2次/d。兩組患者均連續(xù)治療4周。觀察兩組的臨床療效，同時(shí)比較治療前后兩組心理狀況檢驗(yàn)量表（MMSE）評(píng)分、美國(guó)國(guó)立衛(wèi)生研究院卒中量表（NIHSS）評(píng)分、日常生活活動(dòng)能力量表（ADL）評(píng)分的變化情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為88.18%、97.27%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組MMSE評(píng)分、ADL評(píng)分均顯著升高，NIHSS評(píng)分顯著降低，同組治療前后差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，治療組MMSE評(píng)分、ADL評(píng)分高于對(duì)照組，NIHSS評(píng)分低于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 血府逐瘀膠囊聯(lián)合腦苷肌肽注射液治療血管性癡呆具有較好的臨床療效，可改善患者的認(rèn)知功能和日?；顒?dòng)能力，降低神經(jīng)功能缺損程度，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the effect of Xuefu Zhuyu Capsules combined with cattle encephalon glycoside and ignotin in treatment of vascular dementia. Methods Patients (220 cases) with vascular dementia in the Second People's Hospital of Hengshui from January 2012 to December 2014 were randomly divided into control and treatment groups, and each group had 110 cases. Patients in the control group were iv administered with Cattle Encephalon Glycoside and Ignotin Injection, 10 mL/time added into normal saline 250 mL, once daily. The patients in the treatment group were po administered with Xuefu Zhuyu Capsules on the basis of the control group, 6 grains/time, twice daily. The patients in two groups were treated for 4 weeks. After treatment, the efficacy was evaluated, and the changes of MMSE score, NIHSS score, and ADL score in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 88.18% and 97.27%, respectively, and there were differences between two groups (P<0.05). After treatment, MMSE score and ADL score in two groups were significantly elevated, and NIHSS scores were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, MMSE score and ADL score in the treatment group were higher than those in the control group, and NIHSS score was lower than that in the control group, with significant difference between two groups (P<0.05). Conclusion Xuefu Zhuyu Capsules combined with cattle encephalon glycoside and ignotin has clinical curative effect in treatment of vascular dementia, and can improve cognitive function and daily activity ability, also can reduce the nerve function defect degree, which has a certain clinical application value.