目的 探討小牛血清去蛋白注射液聯(lián)合甘露醇治療顱腦損傷的臨床療效。方法 選取2015年2月-2016年2月漢中市中心醫(yī)院神經(jīng)內科收治的顱腦損傷患者150例，按照治療措施的差別分為對照組和治療組，每組各75例。對照組靜脈滴注20%甘露醇注射液125 mL，2次/d。治療組在對照組的基礎上靜脈滴注小牛血清去蛋白注射液，30 mL溶于5%葡萄糖注射液250 mL，1次/d。兩組患者均連續(xù)治療4周。觀察兩組的臨床療效，同時比較兩組簡易智力狀態(tài)檢查量表（MMSE）評分、格拉斯哥昏迷（GCS）評分及血清神經(jīng)元特異性烯醇化酶（NSE）和S100B變化情況。結果 治療后，對照組和治療組總有效率分別為82.67%、92.00%，兩組比較差異具有統(tǒng)計學意義（P<0.05）。治療后，兩組MMSE和GCS評分顯著升高，同組治療前后差異有統(tǒng)計學意義（P<0.05）；治療后治療組MMSE和GCS評分的升高程度優(yōu)于對照組，兩組比較差異有統(tǒng)計學意義（P<0.05）。治療后，兩組血清NSE和S100B較同組治療前均明顯降低，同組比較差異有統(tǒng)計學意義（P<0.05）；且治療后治療組患者血清NSE和S100B的降低程度更明顯，兩組比較差異有統(tǒng)計學意義（P<0.05）。結論 小牛血清去蛋白注射液聯(lián)合甘露醇治療顱腦損傷效果確切，可明顯改善患者神經(jīng)功能，并降低血清NSE和S100B的水平，具有一定的臨床推廣應用價值。

Objective To investigate the clinical effect of Deproteinised Calf Blood Serum Injection combined with mannitol in treatment of craniocerebral injury. Methods Patients (150 cases) with craniocerebral injury in Department of Neurology of Hanzhong Central Hospital from February 2015 to February 2016 were divided into control and treatment groups based on different treatments, and each group had 75 cases. The patients in the control group were iv administered with 20% Mannitol Injection 125 mL, twice daily. The patients in the treatment group were iv administered with Deproteinised Calf Blood Serum Injection on the basis of the control group, 30 mL added into 5% glucose injection 250 mL, once daily. The patients in two groups were treated for 4 weeks. After treatment, the efficacy was evaluated, and the changes of MMSE scores, GCS scores, NSE, and S100B in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 82.67% and 92.00%, respectively, and there were differences between two groups (P<0.05). After treatment, MMSE and GCS scores in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the MMSE and GCS scores in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, serum NSE and S100B in two groups were significantly decreased, and there were differences in the same groups (P<0.05). And the serum NSE and S100B in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Deproteinised Calf Blood Serum Injection combined with mannitol in has definite curative effects in treatment of craniocerebral injury, can significantly improve the neurological function and reduce the serum NSE and S100B levels, which has a certain clinical application value.