目的 探討烏靈膠囊聯(lián)合艾司西酞普蘭和奧氮平治療抑郁癥的臨床療效。方法 收集2012年7月—2015年7月在河南省中醫(yī)院接受治療的抑郁癥患者86例，隨機(jī)分為對照組和治療組，每組各43例。對照組口服草酸艾司西酞普蘭片，10mg/d，2周后根據(jù)病情可加至20 mg/d；同時口服奧氮平片，5 mg/d。治療組在對照組基礎(chǔ)上口服烏靈膠囊，3粒/次，3次/d。兩組患者均連續(xù)治療8周。觀察兩組的臨床療效，同時比較兩組患者治療前后的HAMD和WHOQOL-BREF評分。結(jié)果 治療后，對照組與治療組總有效率分別為79.07%和95.35%，兩組間差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者HAMD評分均降低，同組治療前后差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組降低的更顯著，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者生理健康、心理狀態(tài)、社會關(guān)系和周圍環(huán)境等WHOQOL-BREF評分均較治療前升高，同組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組WHOQOL-BREF評分比對照組的升高更明顯（P<0.05）。結(jié)論 烏靈膠囊聯(lián)合艾司西酞普蘭和奧氮平可有效緩解抑郁癥患者抑郁狀態(tài)，提高生活質(zhì)量。

Objective To observe the clinical efficacies of Wuling Capsules combined with escitalopram and olanzapine in treatment of depression. Methods Patients (86 cases) with depression in Henan Province Hospital of TCM from July 2012 to July 2015 were enrolled in this study and divided into control and treatment groups, and each group had 43 cases. The patients in the control group were po administered with Escitalopram Oxalate Tablets, 10 mg/d, and the dosage could be added to 20 mg/d according to the specific condition after two weeks. In the same time, the patients were po administered with Olanzapine Tablets, 5 mg/d. The patients in the treatment group were po administered with Wuling Capsules on the basis of control group, 3 grains/time, three times daily. The patients in two groups were treated for 8 weeks. After treatment, clinical efficacy was evaluated, and HAMD and WHOQOL-BREF scores in two groups were compared before and after treatment. Results After treatment, the efficacies in the control and treatment groups were 79.07% and 95.35%, respectively, and there was significant difference between groups (P<0.05). After treatment, HAMD scores in two groups were decreased, and the difference was statistically significant in the same group before and after treatment (P<0.05). And the score in the treatment group was lower than that in the control group, with significant difference between two groups (P<0.05). After treatment, the WHOQOL-BREF scores of physical health, psychological status, social relations, and surrounding environment in two groups were increased, and the difference was statistically significant in the same group (P<0.05); And WHOQOL-BREF scores in the treatment group were higher than those in the control group (P<0.05). Conclusion Wuling Capsules combined with escitalopram and olanzapine can effectively alleviate the depression states of patients and improve the quality of life.