目的 優(yōu)化復(fù)方呋塞米螺內(nèi)酯片的處方。方法 以溶出度為指標(biāo)，采用單因素試驗優(yōu)選復(fù)方呋塞米螺內(nèi)酯片的最佳處方影響因素。結(jié)果 優(yōu)選出最佳處方為：以3%十二烷基硫酸鈉（SDS）為表面活性劑，10%微晶纖維素為填充劑，5%交聯(lián)聚維酮（PVPP）為崩解劑以內(nèi)3%外2%法加入的方式制備復(fù)方呋塞米螺內(nèi)酯片。結(jié)論 制備的復(fù)方呋塞米螺內(nèi)酯片表面光潔，硬度適宜，溶出度較好，工藝簡便可行。

Objective To optimize the formulation of Compound Furosemide and Spironolactone Tablets. Methods Dissolution was used as index, and factors of the best prescription carried out by single factor test. Results The best prescription was selected as following:3% SDS was as surfactant, 10% MCC was as filler, and 5% PVPP was as disintegrating agent with adding ways of internal 3% external 2%. Conclusion Compound Furosemide and Spironolactone Tablets has smooth surface, suitable hardness, and good dissolution, and the process is simple and feasible.