目的 探究香菊膠囊聯(lián)合氮卓斯汀治療過敏性鼻炎的臨床療效。方法 選取2014年8月-2015年8月首都醫(yī)科大學(xué)附屬北京潞河醫(yī)院耳鼻喉科收治的過敏性鼻炎患者216例,根據(jù)不同的治療方案分對照組和治療組,每組各108例。對照組給予鹽酸氮卓斯汀鼻噴霧劑,每側(cè)鼻孔1噴/次,2次/d。治療組在對照組基礎(chǔ)上口服香菊膠囊,3粒/次,3次/d。兩組均連續(xù)治療1個月。觀察兩組的臨床療效,同時比較兩組患者的癥狀評分和血清學(xué)指標(biāo)的情況。結(jié)果 治療后,對照組和治療組的總有效率分別為85.19%、93.52%,兩組比較差異有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組患者打噴嚏、流涕、鼻塞、鼻癢及總分均顯著降低,同組治療前后差異有統(tǒng)計學(xué)意義(P<0.05);且治療組這些觀察指標(biāo)改善程度明顯優(yōu)于對照組,兩組比較差異有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組患者IL-12、IFN-γ水平顯著升高,而IL-4、IL-10、IgE水平顯著降低,同組治療前后差異有統(tǒng)計學(xué)意義(P<0.05);且治療組這些觀察指標(biāo)改善程度明顯優(yōu)于對照組,兩組比較差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 香菊膠囊聯(lián)合氮卓斯汀治療過敏性鼻炎具有較好的臨床療效,可緩解臨床癥狀,提高機體的免疫能力,具有一定臨床推廣應(yīng)用價值。

Objective To investigate the effect of Xiangju Capsules combined with azelastine in treatment of allergic rhinitis. Methods Patients (216 cases) with allergic rhinitis in Department of Otolaryngology, Beijing Luhe Hospital Capital Medical University from August 2014 to August 2015 were enrolled into this study. According to the different treatment plans, patients were divided into the control and treatment groups, and each group had 108 cases. Patients in the control group were given Azelastine Hydrochloride Nasal Spray, both nostril 1 spout/time, twice daily. Patients in the treatment group were po administered with Xiangju Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacies were evaluated, and the changes of symptom scores and serology indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.19% and 93.52%, respectively, and there was difference between two groups (P < 0.05). After treatment, the scores of sneezing, runny nose, nasal congestion, and nasal itching, and the total score in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of IL-12 and IFN-γ in two groups were significantly increased, but the levels of IL-4, IL-10, and IgE in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Xiangju Capsules combined with azelastine has clinical curative effect in treatment of allergic rhinitis, and can relieve clinical symptom, improve immune ability, which has a certain clinical application value.