目的 觀察腎復(fù)康膠囊聯(lián)合百令膠囊治療慢性腎小球腎炎的療效。方法 選取2012年1月-2015年12月在天津市第一中心醫(yī)院腎內(nèi)科就診且確診為慢性腎小球腎炎患者95例,隨機(jī)分為對(duì)照組(48例)和治療組(47例)。對(duì)照組患者在常規(guī)治療同時(shí)口服百令膠囊,5粒/次,3次/d。治療組在對(duì)照組的基礎(chǔ)上口服腎復(fù)康膠囊,4粒/次,3次/d。兩組患者均連續(xù)治療12周。觀察記錄兩組患者的臨床總有效率、治療前后24 h尿蛋白定量、尿紅細(xì)胞計(jì)數(shù)(RBC)、尿素氮(BUN)、血肌酐(Scr)的水平變化。結(jié)果 治療后,對(duì)照組和治療組總有效率分別為85.42%、93.62%,兩組差異比較具有統(tǒng)計(jì)學(xué)意義(P<0.05);兩組患者的24 h尿蛋白、RBC、BUN和Scr水平均顯著降低,同組治療前后差異具有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組患者降低程度更為明顯,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 腎復(fù)康膠囊聯(lián)合百令膠囊治療慢性腎小球腎炎具有良好的療效,能夠改善腎功能指標(biāo),具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical effect of Kouyanqing Granules combined with triamcinolone acetonide in treatment of oral lichen planus. Methods The clinical data of 78 patients with oral lichen planus in China Medical University Stomatology Hospital from January 2014 to October 2015 were retrospectively analyzed, and were randomly divided into control group (39 cases) and treatment group (39 cases). All patients were given basic treatment to reduce the stimulation to oral mucosa. The patients in the control group were injected with Triamcinolone Acetonide Acetate Injection in lesion mucosal basement, 10 mg dissolved in 2% lidocaine 2.5 mL, once a week. The patients in the treatment group were po administered with Kouyanqing Granules on the basis of the control group, 2 bags/time, twice daily. The patients in two groups were treated for 4 weeks. After treatment, clinical efficacies in two groups were evaluated. And the changes of scores of physical signs, pain and life quality were compared. In the same time, the levels of serum IL-2, IL-4, and TNF-α in two groups before and after treatment were determined. Results After treatment, the total efficacies in the control group and treatment group were 84.62% and 97.44%, respectively, and there were differences between two groups (P < 0.05). After treatment, the scores of physical signs, pain and life quality in two groups were significantly decreased (P < 0.05), and the scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of serum IL-2, IL-4, and TNF-α in two groups weresignificantly decreased (P < 0.05), and the reductions in treatment group were more obvious, with significant difference between two groups (P < 0.05). Conclusion Kouyanqing Granules combined with triamcinolone acetonide has a significant curative effect in treatment of oral lichen planus, can significantly decrease the levels of serum inflammatory cytokines, and effectively improve clinical symptoms, which has a certain clinical application value.