目的 觀察金錢草顆粒治療術(shù)后腎結(jié)石的臨床療效。方法 選取北京市順義區(qū)醫(yī)院于2013年4月-2015年1月就診的腎結(jié)石患者86例,按隨機(jī)數(shù)字表格法將患者分為對(duì)照組和治療組,每組各43例。對(duì)照組經(jīng)腎鏡輸尿管鏡聯(lián)合三代氣壓彈道碎石術(shù)治療,術(shù)后常規(guī)處理。治療組在對(duì)照組基礎(chǔ)上口服金錢草顆粒,1袋/次,2次/d。兩組均連續(xù)治療4周。觀察兩組的臨床療效,同時(shí)比較兩組實(shí)驗(yàn)室指標(biāo)、中醫(yī)證候總積分和復(fù)發(fā)情況。結(jié)果 治療后,對(duì)照組和治療組的總有效率分別為76.74%、93.02%,兩組總有效率比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組pH值明顯上升,24h尿酸、24h尿鈣水平顯著下降,同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組這些指標(biāo)的改善程度明顯優(yōu)于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組中醫(yī)證候總積分均明顯下降,同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組該指標(biāo)的下降程度明顯低于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療組隨訪6、12個(gè)月結(jié)石復(fù)發(fā)率均明顯低于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 金錢草顆粒治療術(shù)后腎結(jié)石具有較好的臨床療效,顯著減少結(jié)石復(fù)發(fā),具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To observe the effect of Jinqiancao Granules in treatment of postoperative kidney calculus. Methods Patients (86 cases) with kidney calculus in Beijing Shunyi District Hospital from April 2013 to January 2015 were divided into control and treatment groups according to the random number table method, and each group had 43 cases. The patients in the control group were underwent renal endoscopy combined with three generations of pneumatic lithotripsy, and given routine treatment after operation. The patients in the treatment group were po administered with Jinqiancao Granules on the basis of control group, 1 bag/time, twice daily. The patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and laboratory related indexes, total scores of TCM syndrome, and calculi recurrence rate in the two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 76.74% and 93.02%, respectively, and there were differences between two groups (P< 0.05). After treatment, pH values in two groups were significantly increased, levels of 24 h uric acid and 24 h urinary calcium in two groups were significantly decreased, and the differences were statistically significant in the same group (P< 0.05). These observational indexes in treatment group were better than those in control group, with significant difference between two groups (P< 0.05). After treatment, total scores of TCM syndrome in the two groups were significantly decreased, and the difference was statistically significant in the same group (P< 0.05). These observational indexes in treatment group were lower than those in control group, with significant difference between two groups (P< 0.05). Recurrence rates of 6 months and 12 months in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P< 0.05). Conclusion Jinqiancao Granules has clinical curative effect in treatment of postoperative kidney calculus, and can significantly reduce the recurrence rate of kidney calculus, which has a certain clinical application value.