目的 探討舒血寧注射液聯(lián)合鹽酸替扎尼定治療椎動脈型頸椎病的臨床療效。方法 選取2015年1月-2016年1月遂寧市中心醫(yī)院收治的椎動脈型頸椎病患者72例,根據(jù)治療方案的不同分為對照組和治療組,每組各36例。對照組口服鹽酸替扎尼定片,2mg/次,3次/d。治療組在對照組基礎(chǔ)上靜脈滴注舒血寧注射液,20mL用5%葡萄糖溶液稀釋至250mL,1次/d。兩組患者均連續(xù)治療28d。觀察兩組的臨床療效,同時比較治療前后兩組患者的臨床癥狀評分、HAD評分、NRS評分、WHOQOL-BREF評分及生理應(yīng)激指標(biāo)的變化。結(jié)果 治療后,對照組和治療組的總有效率分別為77.78%、94.44%,兩組比較差異有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組患者臨床癥狀評分、HAD評分和NRS評分均較治療前顯著降低,同組治療前后差異有統(tǒng)計學(xué)意義(P<0.05);治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組患者生理健康、心理狀態(tài)、社會關(guān)系及周圍環(huán)境評分均較治療前升高,同組治療前后差異有統(tǒng)計學(xué)意義(P<0.05);治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組空腹血糖均較治療前降低,而餐后胰島素水平均較治療前升高,同組治療前后差異有統(tǒng)計學(xué)意義(P<0.05);治療組這些觀察指標(biāo)的改善程度明顯優(yōu)于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 舒血寧注射液聯(lián)合鹽酸替扎尼定片治療椎動脈型頸椎病具有較好的臨床療效,可提高患者生活質(zhì)量,改善患者生理應(yīng)激狀態(tài),具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Shuxuening Injection combined with Tizanidine Hydrochloride Tablets in treatment of cervical spondylosis of vertebral artery type. Methods Patients (72 cases) with cervical spondylosis of vertebral artery type in Suining Central Hospital from January 2015 to January 2016 were enrolled in this study. According to the different treatment plans, patients were divided into control and treatment groups, and each group had 36 cases. Patients in the control group were po administered with Tizanidine Hydrochloride Tablets, 2 mg/time, three times daily. Patients in the treatment group were iv administered with Shuxuening Injection on the basis of the control group, 20 mL was diluted with 5% glucose into 250 mL, once daily. Patients in two groups were treated for 28 d. After treatment, the efficacy was evaluated, and the scores of clinical symptoms, HAD, NRS, and WHOQOL-BREF, and physiological stress indexes were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.78% and 94.44%, respectively, and there was difference between two groups (P < 0.05). After treatment, the scores of clinical symptoms, HAD, and NRS in two groups were significantly increased, and the differences were statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the scores of physiological health, psychological state, social relationship, and surrounding environment in two groups were increased, and the differences were statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the blood glucose levels in two groups were decreased, but the insulin levels in two groups were increased, and the differences were statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between groups (P < 0.05). Conclusion Shuxuening Injection combined with Tizanidine Hydrochloride Tablets has clinical curative effect in treatment of cervical spondylosis of vertebral artery type, and can improve the quality of life, and the state of physiological stress, which has a certain clinical application value.