目的 探討皮敏消膠囊聯(lián)合復(fù)方甘草酸苷片治療慢性蕁麻疹的臨床療效。方法 選取2014年4月-2015年4月在三亞市慢性病防治中心皮膚科接受診治的慢性蕁麻疹患者78例為研究對(duì)象,根據(jù)治療方案的差別分成對(duì)照組和治療組,每組各39例。對(duì)照組患者口服復(fù)方甘草酸苷片,50 mg/次,3次/d。治療組在對(duì)照組的基礎(chǔ)上口服皮敏消膠囊,4粒/次,3次/d。兩組患者均治療4周。觀察兩組臨床療效,同時(shí)比較兩組患者的癥狀積分、皮膚病生活質(zhì)量指數(shù)(DLQI)評(píng)分和免疫球蛋白E(IgE)變化、不良反應(yīng)及復(fù)發(fā)率。結(jié)果 治療后,對(duì)照組和治療組的總有效率分別為79.49%、94.87%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組患者癥狀積分、DLQI評(píng)分和IgE均顯著降低,同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。且治療后,治療組這些觀察指標(biāo)的改善程度顯著優(yōu)于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,對(duì)照組和治療組的不良反應(yīng)發(fā)生率分別為5.13%、7.69%,兩組比較差異無(wú)統(tǒng)計(jì)學(xué)意義。6個(gè)月內(nèi)對(duì)照組和治療組的復(fù)發(fā)率分別為23.08%、5.13%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 皮敏消膠囊聯(lián)合復(fù)方甘草酸苷片治療慢性蕁麻疹具有很好的療效,能夠降低IgE的水平,減輕患者臨床癥狀,具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy of Piminxiao Capsules combined with Compound Glycyrrhizin Tablets in treatment of chronic urticaria.Methods Patients (78 cases) with chronic urticaria in Department of Dermatology of Sanya Center for Chronic Disease Control from April 2014 to April 2015 were enrolled in this study. According to the difference of treatment plan, the patients were divided into control and treatment groups, and each group had 39 cases. The patients in the control group were po administered with Compound Glycyrrhizin Tablets, 50 mg/time, three times daily. The patients in the treatment group were po administered with Piminxiao Capsules on the basis of control group, 4 grains/time, three times daily. The patients in two groups were treated for 4 weeks. After treatment, the efficacies were evaluated, and symptoms integral, DLQI scores and IgE in two groups were compared.Results After treatment, the clinical efficacies in the control and treatment groups were 79.49% and 94.87%, respectively, and there was difference between two groups (P<0.05). After treatment, symptoms integral, DLQI scores and IgE in two groups were significantly decreased, and the differences were statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the incidence of adverse reactions in the control and treatment groups were 5.13% and 7.69%, respectively, but there was no difference between two groups. The recurernce rate within 6 months in the control and treatment groups were 23.08% and 5.13%, respectively, and there was difference between two groups (P<0.05).Conclusion Compound Glycyrrhizin Tablets combined with Piminxiao Capsules has clinical curative effect in treatment of chronic urticaria, and can reduce the levels of IgE, relieve the clinical symptoms of patients, which has a certain clinical application value.