芪藶強(qiáng)心膠囊是基于絡(luò)病學(xué)氣血水同治理論研制而成的中成藥,近年來(lái)大量研究證據(jù)表明其在治療心力衰竭方面具有很好的療效。該藥物能改善心力衰竭發(fā)生發(fā)展各階段的生理病理基礎(chǔ),其作用機(jī)制包括抑制神經(jīng)內(nèi)分泌的過度激活、保護(hù)血管內(nèi)皮、阻斷離子通道、抑制心室重構(gòu)和代謝重構(gòu)等。綜述了芪藶強(qiáng)心膠囊上述各方面藥理作用的研究進(jìn)展,以期為芪藶強(qiáng)心膠囊的臨床合理使用提供理論依據(jù)和臨床證據(jù)。

Qiliqiangxin Capsules, a Chinese patent drug, is developed based on collateral disease theory of blood-water co-treatment. Recently, many research evidences have shown an obvious effect of Qiliqiangxin Capsules on heart failure. The drug can improve physiological and pathological basis of heart failure with mechanisms including prevention of excessive activation of neuroendocrine, protection of vascular endothelium, blockage of ion channel, and inhibition of ventricular and metabolic remodeling. This paper overviewed the research progress on above-mentioned effects of Qiliqiangxin Capsules in order to provide theoretical and clinical support for its reasonable application in clinic.

國(guó)家中醫(yī)藥管理局"十二五"中醫(yī)心血管科重點(diǎn)?？祈?xiàng)目;天津市中醫(yī)藥管理局中醫(yī)、中西醫(yī)結(jié)合科研專項(xiàng)課題(2015050)