目的 探討丹紅注射液致藥品不良反應(yīng)(ADR)的特點(diǎn)及相關(guān)因素,為臨床合理用藥提供參考。方法 檢索2005—2015年中國學(xué)術(shù)期刊(網(wǎng)絡(luò)版,CNKI)、萬方數(shù)字化期刊全文庫、中文科技期刊全文數(shù)據(jù)庫(維普)報(bào)道的丹紅注射液致ADR的文獻(xiàn),并進(jìn)行統(tǒng)計(jì)、分析。結(jié)果 丹紅注射液引發(fā)的ADR女性明顯多于男性,年齡多集中在51~70歲,以全身損傷、皮膚損傷較為多見,所占構(gòu)成比分別為22.6%、36.9%。在用藥10~30 min出現(xiàn)的例數(shù)最多,占41.3%。給藥途徑均為注射給藥,給藥劑量為20 mL出現(xiàn)的ADR最多,占總?cè)藬?shù)的58.9%。結(jié)論 臨床應(yīng)加強(qiáng)丹紅注射液的合理使用,盡量避免或減少其所致ADR的發(fā)生。

Objective To investigate the characteristics and related factors of adverse drug reactions (ADR) induced by Danhong Injection, and provide reference for clinical rational use of drugs. Methods China Journal Full-text Database (CNKI), Wangfang Database, Chinese Science and Technology Journal Full-text Database (VIP), etc were retrieved from 2005 to 2015, and the documents of ADR induced by Danhong Injection were analyzed and discussed. Results Women with ADR induced by Danhong Injection were more than men, and more were focused on 51—70 years old. The main ADR of Danhong Injection was systemic injury (22.6%) and skin injury (36.9%). The most cases (41.3%) occured in the medication during 10—30 min. The administration dosage was parenteral administration. The most cases (58.9%) occured with the administration dosage of 20 mL. Conclusion The rational use of Danhong Injection should be strengthened, and to avoid or reduce the occurrence of adverse reactions.

黑龍江省教育廳科學(xué)技術(shù)研究項(xiàng)目(12541571)