目的 評價2010—2014年天津市腫瘤醫(yī)院氟尿嘧啶類藥物的使用情況。方法 調(diào)取天津市腫瘤醫(yī)院2010—2014年氟尿嘧啶類藥物的相關(guān)用藥信息,對藥物劑型、使用金額、用藥頻度(DDDs)、日均費用(DDC)及藥品排序比(B/A)進行統(tǒng)計分析。結(jié)果 2010—2014年氟尿嘧啶類藥物的總使用金額和DDDs逐年增長?？ㄅ嗨麨I片、替吉奧膠囊、氟尿嘧啶注射液和氟尿嘧啶植入劑的使用金額呈逐年遞增。替加氟注射液和注射用氟脲苷的使用金額連續(xù)5年遞減。從排序來看,卡培他濱片、氟尿嘧啶植入劑、替吉奧膠囊連續(xù)4年排名前3位。卡培他濱的DDDs排名持續(xù)居于首位。口服劑型的使用金額構(gòu)成比和DDDs構(gòu)成比持續(xù)上漲,普通注射劑的使用金額構(gòu)成比及DDDs構(gòu)成比均明顯下降。氟尿嘧啶類藥物的DDC及排序相對穩(wěn)定,大部分氟尿嘧啶類藥物的B/A值接近于1.00,表明使用金額與使用頻度的同步性較好。結(jié)論 天津市腫瘤醫(yī)院氟尿嘧啶類藥物使用合理,符合安全、有效、經(jīng)濟、方便的原則。

Objective To investigate the utilization of fluorouracil drugs in Tianjin Cancer Hospital from 2010 to 2014. Methods The utilization information of fluorouracil drugs in Tianjin Cancer Hospital from 2010 to 2014 was extracted, and the dosage form of drugs, consumption sum, defined daily doses (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A) were analyzed statistically. Results From 2010 to 2014, the total consumption sums and DDDs of fluorouracil drugs were increasing year by year. The consumption sums of Capecitabine Tablets, Tegafur Gimeracil Oteracil Potassium Capsules, Fluorouracil Injection, and Fluorouracil Implants increased year by year, while the consumption sums of Tegafur Injection and Floxuridine for injection decreased progressively for five years. From the terms of sequences, Capecitabine Tablets, and Tegafur Gimeracil Oteracil Potassium Capsules ranked the Top 3 for four years. DDDs of Capecitabine Tablets ranked the first, persistently. The consumption sums and DDDs constituent ratios of oral formulations continued rising, and those of ordinary injection decreased obviously. DDC and sequences of fluorouracil drugs were relatively stable. B/A of most fluorouracil drugs was closed to 1.00, indicating that the synchronism was better. Conclusion The utilization of fluorouracil drugs in Tianjin Cancer Hospital is reasonable, according with the principle of safety, effectiveness, economy and convenience.