目的 觀察阿拉坦五味丸聯(lián)合莫沙必利治療功能性消化不良的臨床療效。方法 選取2014年1月—2015年1月?？谑旋埲A區(qū)遵譚鎮(zhèn)衛(wèi)生院收治的功能性消化不良患者140例,以就診單雙號為標(biāo)準(zhǔn)進(jìn)行分組,每組各70例。對照組口服枸櫞酸莫沙必利分散片,1片/次,3次/d。治療組在對照組基礎(chǔ)上給予阿拉坦五味丸,溫水口服,11~15粒/次,1~2次/d。兩組均持續(xù)治療4周。觀察兩組的臨床療效,同時(shí)比較兩組治療前后臨床癥狀評分、幽門螺桿菌陽性率、不良反應(yīng)和復(fù)發(fā)情況。結(jié)果 治療后,治療組的總有效率(95.71%)明顯高于對照組(85.71%),兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組患者噯氣、反酸、燒心、食欲不振、惡心嘔吐和上腹不適的癥狀評分均較治療前顯著下降,同組治療前后差異具有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組這些觀察指標(biāo)的改善程度優(yōu)于對照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組幽門螺桿菌陽性率均較治療前顯著降低下降,同組治療前后差異具有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組這些觀察指標(biāo)的改善程度優(yōu)于對照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 阿拉坦五味丸聯(lián)合莫沙必利治療功能性消化不良具有較好的臨床療效,能顯著改善臨床癥狀,降低幽門螺桿菌陽性率,不良反應(yīng)較少,復(fù)發(fā)率低,具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To observe the clinical effect of Alatan Wuwei Pills combined with mosapride in treatment of functional dyspepsia. Methods Patients (140 cases) with functional dyspepsia from January 2014 to January 2015 were divided into control and treatment groups according to the visiting single or even numbers, and each group had 70 cases. The patients in the control group were po administered with Mosapride Citrate Dispersible Tablets, 1 tablet/time, three times daily. The patients in the treatment group were po administered with Alatan Wuwei Pills on the basis of the control group, 11—15 pills/time, once or twice daily. The patients in two groups were treated for four weeks. The clinical efficacies of the two groups were observed; And clinical symptoms scores, helicobacter pylori positive rate, adverse reactions and recurrence before and after treatment were compared between two groups. Results After treatment, the clinical efficacy of patients in treatment group (95.71%) were higher than those in control group (85.71%) with significant difference (P< 0.05). After treatment, the scores of eructation, acid regurgitation, heartburn, loss of appetite, nausea and vomiting, and epigastric discomfort in two groups were significantly decreased, and the difference was statistically significant in the same group (P< 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P< 0.05). After treatment, the helicobacter pylori positive rates in two groups were significantly decreased, and the difference was statistically significant in the same group (P< 0.05). And the observational index in the treatment group were significantly better than those in the control group, with significant difference between two groups (P< 0.05). Conclusion Alatan Wuwei Pills combined with mosapride has clinical curative effect in treatment of functional dyspepsia, and can significantly improve clinical symptoms, reduce helicobacter pylori positive rate, less adverse reactions and lower recurrence rate, which has a certain clinical application value.