目的 探討百樂眠膠囊聯(lián)合氟哌噻噸美利曲辛片治療老年冠心病患者焦慮的療效,為臨床提供參考。方法 選取2011年1月—2014年6月陜西省中醫(yī)醫(yī)院收治的112例老年冠心病伴有焦慮癥的患者,隨機(jī)分為對(duì)照組(56例)和治療組(56例)。兩組均給予常規(guī)藥物治療冠心病,對(duì)照組給予氟哌噻噸美利曲辛片,1片/次,2次/d。治療組在對(duì)照組的基礎(chǔ)上加用百樂眠膠囊,4粒/次,2次/d。兩組患者均連續(xù)治療14 d。觀察兩組的臨床療效,比較兩組患者焦慮評(píng)分、血脂變化情況。結(jié)果 治療后,對(duì)照組和治療組的總有效率分別為73.2%、92.9%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組患者焦慮評(píng)分均明顯降低,差異具有統(tǒng)計(jì)學(xué)意義(P<0.05);并且治療組焦慮評(píng)分降低程度優(yōu)于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組三酰甘油(TG)、總膽固醇(TC)、低密度脂蛋白(LDL-C)水平均下降(P<0.05),并且治療組血脂降低程度優(yōu)于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 百樂眠膠囊聯(lián)合氟哌噻噸美利曲辛片治療老年冠心病伴有焦慮癥患者,可顯著改善臨床癥狀,緩解焦慮,降低血脂水平,減少不良反應(yīng)發(fā)生率,具有較大的臨床借鑒意義。

Objective To evaluate curative effect of Bailemian Capsules combined with flupentixol and melitracen in treatment of senile coronary heart disease with anxiety symptoms, and provide reference for clinic. Methods Patients (112 cases) of senile coronary heart disease with anxiety symptoms in Shaanxi Provincial Chinese Medicine Hospital from January 2011 to June 2014 were randomly divided into control group (56 cases) and treatment group (56 cases). Two groups were given conventional drug treatment of coronary heart disease. Patients in control group were po administered with Flupentixol and Melitracen Tablets, 1 tablet/time, twice daily. Patients in treatment group were po administered with Bailemian Capsules 4 capsules/time on the basis of control group, twice daily. The patients in two groups were treated for 14 d. After treatment, the efficacy was evaluated, and anxiety scores and changes of blood lipid in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 73.2% and 92.9%, respectively, and there were differences between two groups (P < 0.05). After treatment, anxiety scores in two groups were obviously decreased, and the difference was statistically significant in the same group (P < 0.05). The reducing degrees in treatment group were better than those in control group, with significant difference between two groups (P < 0.05). After treatment, the levels of TG, TC, and LDL-C were significantly decreased (P < 0.05), and the observed indexes in treatment group were better than those in control group, with significant difference between two groups (P < 0.05). Conclusion Bailemian Capsules combined Flupentixol and Melitracen Tablets has clinical curative effect in treatment of senile coronary heart disease with anxiety symptoms, and can significantly improve the clinical symptoms, relieve anxiety, decrease the levels of blood lipid, and reduce adverse reactions, which has a certain clinical application value.