目的 探究腦血疏口服液聯(lián)合尼莫地平治療高血壓腦出血的臨床療效。方法 回顧性分析2013年4月—2015年4月延安大學附屬醫(yī)院神經(jīng)外科收治的86例行微創(chuàng)顱內(nèi)血腫清除術的高血壓腦出血患者的臨床資料,按照治療方法不同分為對照組和治療組,每組各43例。所有患者均行微創(chuàng)顱內(nèi)血腫清除術。對照組術后靜脈泵入尼莫地平注射液,泵速1 mg/h,7 d后改為口服尼莫地平片,40 mg/次,3 次/d。治療組在對照組治療基礎上口服腦血疏口服液,10 mL/次,3次/d。兩組均連續(xù)治療4周。觀察兩組的臨床療效,同時比較兩組患者治療前后神經(jīng)功能缺損(NIHSS)評分、血腫量、血腫周圍水腫量、白細胞介素(IL)-4、IL-6、IL-10、腫瘤壞死因子(TNF)-α的變化。結果 治療后,對照組和治療組的總有效率分別為74.42%、93.02%,兩組比較差異具有統(tǒng)計學意義(P< 0.05)。治療后,兩組患者血腫量、血腫周圍水腫量顯著減少,NIHSS評分、IL-4、IL-6、IL-10和TNF-α均顯著降低,同組治療前后差異有統(tǒng)計學意義(P< 0.05);且治療組這些觀察指標的改善程度優(yōu)于對照組,兩組比較差異具有統(tǒng)計學意義(P< 0.05)。結論 腦血疏口服液聯(lián)合尼莫地平治療高血壓腦出血具有很好的臨床療效,可降低炎癥因子水平,促進神經(jīng)功能的恢復,具有一定的臨床推廣應用價值。

Objective To explore the clinical effect of Naoxueshu Oral Liquid combined with nimodipine in treatment of hypertensive cerebral hemorrhage. Methods The clinical data of 86 patients with hypertensive cerebral hemorrhage who were treated in Department of Neurosurgery of Affiliated Hospital of Yan'an University from April 2013 to April 2014 were retrospectively analyzed. The patients were divided into control and treatment groups according to the different therapeutic methods, and each group had 46 cases. All patients were performed minimally invasive removal of intracranial hematoma. The patients in the control group were continuous intravenous pumping Nimodipine Injection after the operation, with the dripping speed of 1 mg/h, once daily. After 7 d, they were po administered with Nimodipine Tablets, 40 mg/time, three times daily. The patients in the treatment group were po administered with Naoxueshu Oral Liquid on the basis of the control group, 10 mL/time, three times daily. The patients in two groups were treated for 7 d. After treatment, the efficacy was evaluated, and the changes of NIHSS scores, hematoma amount, edema volume around the hematoma, IL-4, IL-6, IL-10, and TNF-α in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 74.42% and 93.02%, respectively, and there were differences between two groups (P < 0.05). After treatment, hematoma amount and edema volume around the hematoma in two groups were reduced, and NIHSS scores, IL-4, IL-6, IL-10, and TNF-α were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). These observed indexes in the treatment group were better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Naoxueshu Oral Liquid combined with nimodipine has curative effect in treatment of hypertensive cerebral hemorrhage, and can reduce the level of inflammatory factors, also can promote the recovery of neural function, which has a certain clinical application value.