目的 了解華中科技大學同濟醫(yī)學院附屬協和醫(yī)院腫瘤中心2014年癌痛患者麻醉藥品的使用情況,為臨床合理使用麻醉藥品提供依據。方法 收集2014年1月—2014年12月腫瘤中心麻醉藥品處方10 757張,對麻醉藥品的用藥品種、銷售金額、用藥頻度(DDDs)、日均藥費(DDC)和藥物利用指數(DUI)等進行統(tǒng)計分析。結果 處方中共應用9種麻醉藥品,使用麻醉藥品的癌痛患者中男性略多于女性,41歲以上的中老年患者是癌痛患者的主要人群。銷售金額居前3位的分別是鹽酸羥考酮緩釋片(40 mg)、鹽酸羥考酮緩釋片(10 mg)、芬太尼透皮貼劑(8.4 mg)。DDDs居首位的是磷酸可待因片,鹽酸羥考酮緩釋片(40 mg)次之。除了鹽酸羥考酮緩釋片(40 mg)和芬太尼透皮貼劑(8.4 mg),其他麻醉藥品的DUI均< 1。在所有病種中肺癌的麻醉藥品DDDs最高為22 531.16?？诜?經皮劑型麻醉藥品的DDDs為48 800.50,占總DDDs的97.46%。結論 隨著癌痛規(guī)范化治療示范病房的建立,麻醉藥品的使用基本符合“癌痛三階梯止痛治療指導原則”。

Objective To investigate the use of narcotic drugs in cancer center of Union Hospital Tongji Medical College, Huazhong University of Science and Technology in 2014, and to provide reference for reasonable application of narcotic drugs. Methods The prescription (10 757 pieces) of narcotic drugs in cancer center from January 2014 to December 2014 was collected, and drug category, consumption sums, average daily cost (DDC), defined daily dose system (DDDs), and drug utilization index (DUI) were analyzed statistically. Results Nine kinds of narcotic drugs were used. There were slightly more male patients than female patients. Elderly patients over the age of 41 were the main group of patients with cancer pain. The narcotic drugs with top three consumption sums were Oxycodone Hydrochloride Prolonged-release Tablets (40 mg), Oxycodone Hydrochloride Prolonged-release Tablets (10 mg), and Fentanyl Transdermal Patch (8.4 mg). DDDs of Codeine Phosphate Tablet ranked the first, while Oxycodone Hydrochloride Prolonged-release Tablets (40 mg) took the second place. The DUI index of Oxycodone Hydrochloride Prolonged-release Tablets (40 mg) and Fentanyl Transdermal Patch (8.4 mg) were more than 1, while the others were low than 1. The DDDs of narcotic drugs in lung cancer was up to 22 531.16, much higher than any other kind of tumor. DDDs of oral/percutaneous narcotics was 48 800.50, accounting for 97.46% of the total DDDs. Conclusion Along with the establishment of “GPM ward”, application of narcotic analgesic is reasonable and in line with the suggests of “three-tiered cancer pain ladder” on the whole.