目的 觀察復方阿嗪米特聯(lián)合莫沙必利治療兒童功能性消化不良的臨床療效。方法 選取2011年12月—2014年10月延安市人民醫(yī)院收治的功能性消化不良患兒80例,隨機分為對照組和治療組,每組各40例。對照組患兒餐前15 min口服枸櫞酸莫沙必利片5 mg/次,3次/d。治療組患兒在對照組基礎(chǔ)上口服復方阿嗪米特腸溶片,2片/次,3次/d。兩組患兒均連續(xù)治療1個月。觀察兩組的臨床療效,同時比較治療前后兩組患兒上腹痛、餐后飽脹、上腹部灼燒感、噯氣的評分變化。結(jié)果 治療后,對照組和治療組的總有效率分別為75.0%、87.5%,兩組比較差異有統(tǒng)計學意義(P< 0.05)。治療后,兩組上腹痛評分、餐后飽脹評分、上腹部灼燒感評分、噯氣評分均較治療前顯著降低,同組治療前后差異有統(tǒng)計學意義(P< 0.05);治療組這些指標評分的降低程度顯著優(yōu)于對照組,兩組比較差異具有統(tǒng)計學意義(P< 0.05)。對照組和治療組的不良反應(yīng)發(fā)生率分別為10.0%、12.5%,兩組不良反應(yīng)發(fā)生率比較差異無統(tǒng)計學意義。結(jié)論 復方阿嗪米特聯(lián)合莫沙必利治療兒童功能性消化不良具有較好的臨床療效,可有效緩解各種功能性消化不良的臨床癥狀,不良反應(yīng)小,具有一定的臨床推廣應(yīng)用價值。

Objective To observe the efficacy of compound azintamide combined with mosapride in treatment of functional dyspepsia of children. Methods Patients (80 cases) with functional dyspepsia in Yan'an People's Hospital from December 2011 to October 2014were randomly divided into control and treatment groups, and each group had 40 cases. The patients in the control group were po administered with Mosapride Citrate Tablets 15 min before a meal, 5 mg/time, three times daily. The patients in the treatment group were po administered with Compound Azintamide Enteric-coated Tablets on the basis of the control group, two tablets/time, three times daily. The patients in two groups were treated for 1 month. After treatment, the efficacy was evaluated, the changes of abdominal pain score, postprandial full bilge score, burning score, and belching score in two groups before and after treatment were compared. Results After the treatment, the efficacies in the control and treatment groups were 75.0% and 87.5%, respectively, and there was difference between two groups (P < 0.05). After treatment, abdominal pain score, postprandial full bilge score, burning score, and belching score in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). The reduction extent of these indicators score in the treatment group was better than those in the control group, with significant difference between two groups (P < 0.05). The incidence of adverse reactions in the control and treatment groups were 10.0% and 12.5%, respectively, and there was no difference between two groups. Conclusion Compound azintamide combined with mosapride has good clinical effect in treatment of functional dyspepsia of children, and can effectively relieve clinical symptoms of functional dyspepsia with less adverse reactions, which has a certain clinical application value.