目的 探討麝香保心丸聯(lián)合阿托伐他汀治療急性心肌梗死的臨床療效。方法 選擇2012年1月—2014年12月荊門市第二人民醫(yī)院收治的急性心肌梗死患者120例,隨機(jī)分為治療組和對照組,每組各60例,對照組在基礎(chǔ)治療的基礎(chǔ)上口服阿托伐他汀片80 mg/d。治療組在對照組的基礎(chǔ)上給予麝香保心丸,2丸/次,3次/d,兩組患者均連續(xù)治療10周。比較兩組的臨床療效、并發(fā)癥發(fā)生情況以及血漿中乳酸脫氫酶(LDH)、心肌鈣蛋白(cTnT)、超氧化物歧化酶(SOD)及肌酸激酶同工酶(CK-MB)水平。結(jié)果 治療組總有效率明顯高于對照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P< 0.05);治療2周后,治療組并發(fā)癥發(fā)生率為33.33%,顯著低于對照組,比較差異有統(tǒng)計(jì)學(xué)意義(P< 0.05);治療24 h后,兩組患者血漿中LDH、cTnT、SOD及CK-MB水平均顯著高于治療前,且兩組比較差異有統(tǒng)計(jì)學(xué)意義(P< 0.05);治療24 h后,治療組的LDH、cTnT及CK-MB水平顯著低于對照組,SOD水平顯著高于對照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P< 0.05)。結(jié)論 麝香保心丸聯(lián)合阿托伐他汀治療急性心肌梗死具有較好的臨床療效,顯著降低并發(fā)癥發(fā)生率,值得臨床推廣。

Objective To investigate the clinical effect of Shexiang Baoxin Pills combined with atorvastatin in treatment of acute myocardial infarction. Methods Patients (120 cases) with acute myocardial infarction in Jingmen No. 2 People's Hospital from January 2012 to December 2014 were randomly divided into control and treatment groups. Each group had 60 cases. Patients in control group were po given Atorvastatin Tablets 80 mg/d on the basis of conventional therapy. Patients in treatment group were given Shexiang Baoxin Pills 2 pills/time, three times daily. The patients in two groups were treated for 8 weeks. The efficacy, occurrence of complications, lactic dehydrogenase (LDH), cardiac troponin (cTnT), superoxide dismutase (SOD), and creatine kinase isoenzyme (CK-MB) in plasma between patients of two groups were compared. Results The clinical efficacy in treatment group was higher than that in control group with significant difference (P < 0.05). After treatment for 2 weeks, the incidence of complications in treatment group was 33.33%, significantly lower than that of control group, and the difference was statistically significant (P < 0.05). After treatment for 24 h, the levels of LDH, cTnT, SOD, and CK-MB of two groups were significantly higher than those before treatment with significant differences (P < 0.05). The levels of LDH, cTnT, and CK-MB in treatment group were significantly lower than those of control group, and the level of SOD was significantly higher than that in control group, with significant difference (P < 0.05). Conclusion Shexiang Baoxin Pills combined with atorvastatin has good efficacy in treatment of acute myocardial infarction, and also can reduce the incidence of complications, which has a certain clinical application value.