1H-NMR、MS 確證了結構.此路線的總收率為47.89%,質量分數為99.66%.結論 該合成工藝設計合理,操作簡單,適用于工業(yè)化生產,鹽酸維拉佐酮的收率和純度較高.;Objective To study the synthetic technology of vilazodone hydrochloride. Methods 5-Cyanoindole was used as starting material to synthesize vilazodone by Friedel-Craft reaction, reduction reaction, sulfonylation reaction, and condensation reaction. Then vilazodone hydrochloride was synthesized by reacting with hydrochloric acid. Results The target compound was synthesized and characterized by 1H-NMR and MS. The total yield of vilazodone hydrochloride with the purity of 99.66% was 47.89%. Conclusion The synthetic route of vilazodone hydrochloride has the advantages of reasonable design and simple operation with high yield and purity, and is suitable for industrial production."/>

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首頁 > 過刊瀏覽>2015年第30卷第7期 >2015,30(7):753-756. DOI:10.7501/j.issn.1674-5515.2015.07.001
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鹽酸維拉佐酮的合成工藝研究

Synthesis of vilazodone hydrochloride

發(fā)布日期:2015-07-21