目的 探討丁苯酞聯(lián)合阿司匹林治療急性分水嶺腦梗死的臨床療效。方法 選取2012年10月—2014年10月天津市寶坻區(qū)人民醫(yī)院收治的急性分水嶺腦梗死患者100例,隨機分為對照組和治療組,每組50例。對照組在對癥治療的基礎(chǔ)上口服阿司匹林腸溶片,2片/次,3次/d。治療組在對照組治療的基礎(chǔ)上口服丁苯酞軟膠囊,2粒/次,3次/d。兩組患者均連續(xù)治療15 d。觀察兩組患者的臨床療效,同時比較兩組治療前后血脂水平、血糖、血流量、血壓、神經(jīng)功能缺損評分、Barthel指數(shù)的變化。結(jié)果 治療后,對照組和治療組總有效率分別為72.0%、94.0%,兩組總有效率比較差異具有統(tǒng)計學(xué)意義(P < 0.05)。兩組患者的TC、TG、LDL、血糖、收縮壓、舒張壓、神經(jīng)功能缺損評分均較治療前顯著降低,血流量、Barthel指數(shù)均較治療前顯著升高,同組治療前后差異有統(tǒng)計學(xué)意義(P < 0.05);且治療組這些觀察指標(biāo)的改善程度優(yōu)于對照組,兩組比較差異有統(tǒng)計學(xué)意義(P < 0.05)。結(jié)論 丁苯酞聯(lián)合阿司匹林治療急性分水嶺腦梗死具有較好的臨床療效,能改善患者的神經(jīng)功能缺損程度,提高患者的生活質(zhì)量,值得臨床推廣應(yīng)用。

Objective To observe the clinical effect of butylphthalide combined with aspirin in treatment of acute watershed cerebral infarction. Methods Patients (100 cases) with acute watershed cerebral infarction in Tianjin Baodi Hospital from October 2012 to October 2014 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the control group were po administered with Aspirin Enteric-coated Tablets on the basis of symptomatic treatment, 2 tablets/time, three times daily. The patients in the treatment group were po administered with Butylphthalide Soft Capsules on the basis of control group, 2 grains/time, three times daily. Two groups were treated for 15 d. After treatment, the efficacy was evaluated, and the changes of lipid levels, blood sugar, blood flow, blood pressure, neural function defect scale and Barthel index in two groups were compared. Results The efficacies in the control and treatment groups were 72.0% and 94.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, TC, TG, LDL, blood glucose, systolic pressure, diastolic blood pressure, and neural function defect scale in two groups were significantly reduced, blood flow and Barthel index was significantly increased, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant differences between two groups (P < 0.05). Conclusion Butylphthalide combined with aspirin has the good clinical effect in treatment of acute watershed cerebral infarction, and can improve the nerve function defect degree, while also can improve the life quality of patients, which is worth clinical promotion.