目的 探討鹽酸米諾環(huán)素軟膏治療慢性牙周炎的臨床療效。方法 選取2013年8月—2014年8月遂寧市中心醫(yī)院收治的80例慢性牙周炎患者共94顆患牙,隨機(jī)分為對(duì)照組和治療組,每組47顆患牙。兩組患者均給予常規(guī)齦上潔治術(shù)及齦下刮治術(shù)等基礎(chǔ)治療。對(duì)照組患者在牙周袋內(nèi)注入碘甘油。治療組將鹽酸米諾環(huán)素軟膏放入患牙牙周袋內(nèi),直至溢出。兩組患者每周1次,共4次。觀察兩組患者的臨床療效,同時(shí)比較兩組牙周袋深度(PD)、菌斑指數(shù)(PLI)、牙周附著水平(AL)、齦溝出血指數(shù)(SBI)、C反應(yīng)蛋白(CRP)及白介素-6(IL-6)的變化。結(jié)果 治療后,對(duì)照組和治療組總有效率分別為78.72%、95.74%,兩組總有效率比較差異具有統(tǒng)計(jì)學(xué)意義(P < 0.05)。治療后,兩組的PD、PLI、AL、SBI均較同組治療前顯著降低,同組治療前后差異有統(tǒng)計(jì)學(xué)意義(P < 0.05),且治療組這些觀察指標(biāo)的改善程度優(yōu)于對(duì)照組,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P < 0.05)。治療組CRP較治療前顯著降低,且治療后顯著低于對(duì)照組(P < 0.05)。結(jié)論 鹽酸米諾環(huán)素軟膏治療慢性牙周炎療效顯著,能有效改善牙周炎癥,同時(shí)對(duì)患者機(jī)體的系統(tǒng)炎癥狀態(tài)起到一定的緩解作用,值得推廣應(yīng)用。

Objective To investigate the effect of Minocycline Hydrochloride Ointment in treatment of chronic periodontitis. Methods A total of 94 teeth in 80 patients in Suining Central Hospital from August 2013 to August 2014 were randomly divided into control and treatment groups, and each group had 47 teeth. Two groups of patients were given foundation treatment such as conventional supragingival and subgingival curettage surgery. Patients in the control group were given iodine glycerin in the periodontal pocket. Patients in the treatment group were given Minocycline Hydrochloride Ointment in periodontal pockets until the overflow. Two groups of patients were given once a week, and a total of four times. After treatment, the efficacy was evaluated, and the changes of PD, PLI, AL, SBI, CRP, and IL-6 in two groups were compared. Results The efficacies in the control and treatment groups were 78.72% and 95.74%, respectively, and there were differences between two groups (P < 0.05). After treatment, PD, PLI, AL, and SBI in two groups were significantly reduced, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant difference between two groups (P < 0.05). CRP in treatment group was significantly decreased, and it was lower than that in the control group (P < 0.05). Conclusion Minocycline Hydrochloride Ointment has significant effect in treatment of chronic periodontitis, and can effectively improve periodontal inflammation. At the same time, it plays a role on alleviating inflammation, which is worth clinical promotion.

國(guó)家自然科學(xué)基金資助項(xiàng)目(30973323)