目的 探討鹽酸川芎嗪聯(lián)合甲鈷胺治療股外側(cè)皮神經(jīng)炎的臨床療效.方法 選取2013年9月—2014年9月哈爾濱理工大學(xué)校醫(yī)院收治的股外側(cè)皮神經(jīng)炎患者60例,隨機(jī)分為對(duì)照組和治療組,每組30例.對(duì)照組口服甲鈷胺片,0.5 mg/次,3次/d.治療組在對(duì)照組的基礎(chǔ)上,穴位注射鹽酸川芎嗪注射液2 mL,1次/d.兩組均連續(xù)治療30 d.觀察兩組的臨床療效,同時(shí)比較兩組神經(jīng)傳導(dǎo)速度、疼痛緩解程度、疼痛開始緩解時(shí)間、疼痛持續(xù)時(shí)間.結(jié)果 治療后,對(duì)照組和治療組的總顯效率分別為70%、90%,兩組總顯效率比較差異有統(tǒng)計(jì)學(xué)意義(P< 0.05).治療后,治療組患者疼痛緩解程度明顯高于對(duì)照組,且治療組疼痛開始緩解時(shí)間、疼痛持續(xù)時(shí)間均明顯短于對(duì)照組,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P< 0.05).治療后兩組患側(cè)大腿神經(jīng)傳導(dǎo)速度均明顯提高,同組治療前后差異有統(tǒng)計(jì)學(xué)意義(P< 0.05),治療后治療組神經(jīng)傳導(dǎo)速度高于對(duì)照組,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P< 0.05).結(jié)論 鹽酸川芎嗪聯(lián)合甲鈷胺治療股外側(cè)皮神經(jīng)炎具有較好的臨床療效,可有效提高神經(jīng)傳導(dǎo)速度,改善臨床癥狀,不良反應(yīng)少,值得臨床推廣應(yīng)用.

Objective To observe the clinical efficacy of ligustrazine hydrochloride combined with mecobalamin in treatment of lateral femoral cutaneous neuritis. Methods Patients (60 cases) with lateral femoral cutaneous neuritis in the School Hospital of Harbin University of Science and Technology from September 2013 to September 2014 were randomly divided into control and treatment groups, and each group had 30 cases. The patients in the control group were po administered with Mecobalamin Tablets, 0.5 mg/time, three times daily. The patients in the treatment group were given acupoint injection 2 mL of Ligustrazine Hydrochloride Injection, once daily, and other treatment was the same as the control group. Two groups were treated for 30 d. After treatment, the efficacy was evaluated, and nerve conduction velocity, degree of pain relief, and time of pain began to ease, pain duration time in two groups were compared. Results The significant efficacies in the control and treatment groups were 70% and 90%, respectively, and there were differences between two groups (P <0.05). After treatment, the degree of pain relief in the treatment group was significantly higher than that in control group, while time of pain began to ease, pain duration time in the treatment group were shorter than those in the control group, and there were differences between two groups (P <0.05). After treatment, the lateral thigh nerve conduction velocity in two groups was significantly improved, and the difference was statistically significant in the same group (P <0.05). The nerve conduction velocity in treatment group was higher than that in the control group, and there were differences between two groups (P <0.05). Conclusion Ligustrazine hydrochloride combined with mecobalamin has the good clinical effect in treatment of lateral femoral cutaneous neuritis, and can effectively increase the ipsilateral nerve conduction velocity, while can improve the clinical symptoms with no adverse reaction, which is worth clinical promotion.