0.05). For the hematological analyses, no parameters demonstrated significant changes in all groups during the entire study. During the serum biochemical analyses, there were significant increases of creatinine (CR) level in 5.00 g/kg both sexes and blood urea nitrogen (BUN) level in 5.00 g/kg female rats at the 45th day. Thereafter, significant increase of CR level in 5.00 g/kg male rats were observed at the end of the study (P <0.05, 0.01), but the other indexes were in the normal range. In 5.00 g/kg dose group, remarkable histopathological changes were observed in kidney and intestine of the SD rats. Conclusion R. laxa var. mollis fruit extract could be harmful to kidneys and intestines of the SD rats at 5.00 g/kg dose. No observed adverse effect level (NOAEL) is 2.50 g/kg."/>

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首頁 > 過刊瀏覽>2015年第30卷第4期 >2015,30(4):380-385. DOI:10.7501/j.issn.1674-5515.2015.04.007
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毛葉疏花薔薇果提取物的亞慢性毒性研究

Subchronic toxicity of Rosa laxa var. mollis fruit extract

發(fā)布日期:2015-04-23