目的 觀察腦苷肌肽聯(lián)合丁苯酞治療老年腦梗死的臨床療效。方法 選取2011年3月—2014年5月佛山市三水區(qū)人民醫(yī)院收治的老年腦梗死患者106例,隨機(jī)分為對(duì)照組和治療組,每組53例。對(duì)照組靜脈滴注丁苯酞氯化鈉注射液100 mL/次,2次/d。治療組靜脈滴注腦苷肌肽注射液20 mL,加入5%葡萄糖注射液300 mL,1次/d,其他治療同對(duì)照組。兩組均連續(xù)治療14 d。比較兩組的臨床療效,同時(shí)比較兩組治療前后的NIHSS、mRS評(píng)分和Barthel指數(shù)(BI)變化。結(jié)果 對(duì)照組和治療組總有效率分別為73.58%、90.57%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P < 0.05)。兩組患者治療后NIHSS評(píng)分、mRS評(píng)分均顯著降低,BI顯著升高,同組治療前后差異有統(tǒng)計(jì)學(xué)意義(P < 0.05);治療后治療組這些觀察指標(biāo)改善程度優(yōu)于對(duì)照組,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P < 0.05)。結(jié)論 腦苷肌肽聯(lián)合丁苯酞治療老年腦梗死患者的臨床療效顯著,能夠提高患者的生活質(zhì)量,改善患者神經(jīng)細(xì)胞的功能,值得臨床推廣應(yīng)用。

Objective To observe the clinical effect of cattle encephalon glycoside and ignotin combined with butylphthalide in treatment of senium cerebral infarction. Methods The patients with senium cerebral infarction (106 cases) of Sanshui District People's Hospital of Foshan City from March 2011 to May 2014 were randomly divided into control and treatment groups, and each group had 53 cases. The patients in the control group were iv administered with Butylphthalide and Sodium Chloride Injection, 100 mL/time, twice daily. The patients in the treatment group were iv administered with Cattle Encephalon Glycoside and Ignotin Injection (20 mL diluted with 300 mL 5% glucose injection), once daily, and other treatment was the same as control group. The patients in two groups were treated for 14 d. After treatment, the efficacy was evaluated, and the changes of NIHSS, mRS scores, and BI were compared. Results The efficacies in the control and treatment groups were 73.58% and 90.57%, respectively, and there were differences between two groups (P < 0.05). After treatment, NIHSS, and mRS scores in two groups were significantly reduced, while BI were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the indicators in treatment group improved better than those in control group, with the significant difference between two groups (P < 0.05). Conclusion Cattle encephalon glycoside and ignotin combined with butylphthalide has a good clinical effect in treatment of senium cerebral infarction, and can improve the life quality of patients and function of nerve cells, which is worth clinical promotion.